Seroatlas · Human Serome Atlas

MOGAT3

2-acylglycerol O-acyltransferase 3

Also known as: DC7, DGAT2L2, MGAT3, MOGT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VF5
Gene: MOGAT3
Ensembl: ENSG00000106384
Chromosome: 7
Canonical length: 341 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q86VF5|MOGAT3
     1  MGVATTLQPP TTSKTLQKQH LEAVGAYQYV LTFLFMGPFF SLLVFVLLFT SLWPFSVFYL
    61  VWLYVDWDTP NQGGRRSEWI RNRAIWRQLR DYYPVKLVKT AELPPDRNYV LGAHPHGIMC
   121  TGFLCNFSTE SNGFSQLFPG LRPWLAVLAG LFYLPVYRDY IMSFGLCPVS RQSLDFILSQ
   181  PQLGQAVVIM VGGAHEALYS VPGEHCLTLQ KRKGFVRLAL RHGASLVPVY SFGENDIFRL
   241  KAFATGSWQH WCQLTFKKLM GFSPCIFWGR GLFSATSWGL LPFAVPITTV VGRPIPVPQR
   301  LHPTEEEVNH YHALYMTALE QLFEEHKESC GVPASTCLTF I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOGAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

duodenum: 23 nTPM
small intestine: 22 nTPM
liver: 17 nTPM
colon: 12 nTPM
rectum: 6.8 nTPM
appendix: 1.5 nTPM

Single-cell type

enterocytes: 160 nCPM
colonocytes: 98 nCPM
paneth cells: 39 nCPM
enteric transient amplifying cells: 37 nCPM
goblet cells: 18 nCPM
enteric stem cells: 14 nCPM

Immune cell

neutrophil: 0.8 nTPM
basophil: 0.7 nTPM
NK-cell: 0.5 nTPM
eosinophil: 0.3 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebellum: 6.1 nTPM
white matter: 5.4 nTPM
cerebral cortex: 4.8 nTPM
amygdala: 4.4 nTPM
hippocampal formation: 4.4 nTPM
pons: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOGAT3 as an antibody target. Whether an autoantibody or antibody against MOGAT3 could matter depends on whether native MOGAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOGAT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOGAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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