DGAT2L6
Diacylglycerol O-acyltransferase 2-like protein 6
Also known as: DC3, DG2L6_HUMAN, FLJ25989
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZPD8
- Gene
- DGAT2L6
- Ensembl
- ENSG00000184210
- Chromosome
- X
- Canonical length
- 337 aa
- Protein class
- Metabolic proteins, Predicted membrane proteins
OverviewNCBI Gene
This gene is a member of the diacylglycerol acyltransferase 2 family. The encoded protein is a putative acyltransferase and is most likely involved in the synthesis of di- or triacylglycerol, however its substrate specificity is currently unknown. [provided by RefSeq, Feb 2015]
Canonical amino-acid sequenceUniProt
337 residues, UniProt reviewed canonical sequence.
>Q6ZPD8|DGAT2L6
1 MAFFSRLNLQ EGLQTFFVLQ WIPVYIFLGA IPILLIPYFL LFSKFWPLAV LSLAWLTYDW
61 NTHSQGGRRS AWVRNWTLWK YFRNYFPVKL VKTHDLSPKH NYIIANHPHG ILSFGVFINF
121 ATEATGIARI FPSITPFVGT LERIFWIPIV REYVMSMGVC PVSSSALKYL LTQKGSGNAV
181 VIVVGGAAEA LLCRPGASTL FLKQRKGFVK MALQTGAYLV PSYSFGENEV FNQETFPEGT
241 WLRLFQKTFQ DTFKKILGLN FCTFHGRGFT RGSWGFLPFN RPITTVVGEP LPIPRIKRPN
301 QKTVDKYHAL YISALRKLFD QHKVEYGLPE TQELTITLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DGAT2L6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 6.1 nTPM
Expression across tissuesHPA
Tissue
- skin: 6.1 nTPM
- breast: 1.9 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- epicardial cells: 9.1 nCPM
- myonuclei: 8.2 nCPM
- adipocytes: 7.8 nCPM
- fibro-adipogenic progenitors: 6.2 nCPM
- schwann cells: 4.2 nCPM
- cardiomyocytes: 4.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.6 nTPM
- cerebral cortex: 0.5 nTPM
- thalamus: 0.5 nTPM
- white matter: 0.5 nTPM
- amygdala: 0.4 nTPM
- basal ganglia: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.67
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.49
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DGAT2L6 as an antibody target. Whether an autoantibody or antibody against DGAT2L6 could matter depends on whether native DGAT2L6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DGAT2L6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DGAT2L6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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