Seroatlas · Human Serome Atlas

DGAT2

Diacylglycerol O-acyltransferase 2

Also known as: DGAT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PD7
Gene
DGAT2
Ensembl
ENSG00000062282
Chromosome
11
Canonical length
388 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q96PD7|DGAT2
     1  MKTLIAAYSG VLRGERQAEA DRSQRSHGGP ALSREGSGRW GTGSSILSAL QDLFSVTWLN
    61  RSKVEKQLQV ISVLQWVLSF LVLGVACSAI LMYIFCTDCW LIAVLYFTWL VFDWNTPKKG
   121  GRRSQWVRNW AVWRYFRDYF PIQLVKTHNL LTTRNYIFGY HPHGIMGLGA FCNFSTEATE
   181  VSKKFPGIRP YLATLAGNFR MPVLREYLMS GGICPVSRDT IDYLLSKNGS GNAIIIVVGG
   241  AAESLSSMPG KNAVTLRNRK GFVKLALRHG ADLVPIYSFG ENEVYKQVIF EEGSWGRWVQ
   301  KKFQKYIGFA PCIFHGRGLF SSDTWGLVPY SKPITTVVGE PITIPKLEHP TQQDIDLYHT
   361  MYMEALVKLF DKHKTKFGLP ETEVLEVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DGAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
447 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 447 nTPM
  • liver: 310 nTPM
  • skin: 147 nTPM
  • breast: 135 nTPM
  • blood vessel: 37 nTPM
  • testis: 37 nTPM

Single-cell type

  • neutrophils: 399 nCPM
  • early spermatids: 356 nCPM
  • adipocytes: 313 nCPM
  • esophageal apical cells: 187 nCPM
  • hepatocytes: 145 nCPM
  • late primary spermatocytes: 134 nCPM

Immune cell

  • neutrophil: 351 nTPM
  • eosinophil: 138 nTPM
  • classical monocyte: 22 nTPM
  • basophil: 20 nTPM
  • naive B-cell: 7.6 nTPM
  • memory B-cell: 7.5 nTPM

Brain region

  • basal ganglia: 21 nTPM
  • hypothalamus: 11 nTPM
  • cerebral cortex: 9.3 nTPM
  • pons: 8.3 nTPM
  • choroid plexus: 8.1 nTPM
  • white matter: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.82
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DGAT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DGAT2 as an antibody target. Whether an autoantibody or antibody against DGAT2 could matter depends on whether native DGAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DGAT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DGAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DGAT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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