Seroatlas · Human Serome Atlas

MOGAT2

2-acylglycerol O-acyltransferase 2

Also known as: DGAT2L5, FLJ22644, MGAT2, MOGT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3SYC2
Gene: MOGAT2
Ensembl: ENSG00000166391
Chromosome: 11
Canonical length: 334 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q3SYC2|MOGAT2
     1  MVEFAPLFMP WERRLQTLAV LQFVFSFLAL AEICTVGFIA LLFTRFWLLT VLYAAWWYLD
    61  RDKPRQGGRH IQAIRCWTIW KYMKDYFPIS LVKTAELDPS RNYIAGFHPH GVLAVGAFAN
   121  LCTESTGFSS IFPGIRPHLM MLTLWFRAPF FRDYIMSAGL VTSEKESAAH ILNRKGGGNL
   181  LGIIVGGAQE ALDARPGSFT LLLRNRKGFV RLALTHGAPL VPIFSFGEND LFDQIPNSSG
   241  SWLRYIQNRL QKIMGISLPL FHGRGVFQYS FGLIPYRRPI TTVVGKPIEV QKTLHPSEEE
   301  VNQLHQRYIK ELCNLFEAHK LKFNIPADQH LEFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOGAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

small intestine: 45 nTPM
duodenum: 42 nTPM
liver: 24 nTPM
colon: 13 nTPM
rectum: 12 nTPM
appendix: 1.8 nTPM

Single-cell type

enterocytes: 210 nCPM
hepatocytes: 100 nCPM
colonocytes: 71 nCPM
goblet cells: 46 nCPM
enteric transient amplifying cells: 42 nCPM
paneth cells: 23 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.4 nTPM
medulla oblongata: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
thalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.01
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOGAT2 as an antibody target. Whether an autoantibody or antibody against MOGAT2 could matter depends on whether native MOGAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOGAT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOGAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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