MOGAT1
2-acylglycerol O-acyltransferase 1
Also known as: DGAT2L, DGAT2L1, MGAT1, MOGT1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96PD6
- Gene
- MOGAT1
- Ensembl
- ENSG00000124003
- Chromosome
- 2
- Canonical length
- 335 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum,Cytosol
OverviewNCBI Gene
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
335 residues, UniProt reviewed canonical sequence.
>Q96PD6|MOGAT1
1 MKVEFAPLNI QLARRLQTVA VLQWVLKYLL LGPMSIGITV MLIIHNYLFL YIPYLMWLYF
61 DWHTPERGGR RSSWIKNWTL WKHFKDYFPI HLIKTQDLDP SHNYIFGFHP HGIMAVGAFG
121 NFSVNYSDFK DLFPGFTSYL HVLPLWFWCP VFREYVMSVG LVSVSKKSVS YMVSKEGGGN
181 ISVIVLGGAK ESLDAHPGKF TLFIRQRKGF VKIALTHGAS LVPVVSFGEN ELFKQTDNPE
241 GSWIRTVQNK LQKIMGFALP LFHARGVFQY NFGLMTYRKA IHTVVGRPIP VRQTLNPTQE
301 QIEELHQTYM EELRKLFEEH KGKYGIPEHE TLVLKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MOGAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- gallbladder: 16 nTPM
- liver: 3.1 nTPM
- adipose tissue: 0.8 nTPM
- kidney: 0.7 nTPM
- epididymis: 0.6 nTPM
- skin: 0.6 nTPM
Single-cell type
- breast lactating cells: 241 nCPM
- adipocytes: 146 nCPM
- proximal tubule cells: 41 nCPM
- cholangiocytes: 38 nCPM
- hepatocytes: 37 nCPM
- cardiomyocytes: 32 nCPM
Immune cell
- plasmacytoid DC: 0.7 nTPM
- classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- midbrain: 2.2 nTPM
- cerebral cortex: 1.8 nTPM
- pons: 1.3 nTPM
- amygdala: 1.1 nTPM
- medulla oblongata: 1.1 nTPM
- thalamus: 1.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.55
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.46
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MOGAT1 as an antibody target. Whether an autoantibody or antibody against MOGAT1 could matter depends on whether native MOGAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MOGAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MOGAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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