TET3

Protein identityUniProt · HPA

UniProt accession

O43151

Gene

TET3

Ensembl

ENSG00000187605

Chromosome

2

Canonical length

1795 aa

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; methyl-CpG binding activity; and zinc ion binding activity. Involved in positive regulation of transcription by RNA polymerase II and protein O-linked glycosylation. Predicted to be located in cytoplasm and male pronucleus. Predicted to be active in nucleus. Biomarker of esophagus squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1795 residues, UniProt reviewed canonical sequence.

>O43151|TET3
     1  MSQFQVPLAV QPDLPGLYDF PQRQVMVGSF PGSGLSMAGS ESQLRGGGDG RKKRKRCGTC
    61  EPCRRLENCG ACTSCTNRRT HQICKLRKCE VLKKKVGLLK EVEIKAGEGA GPWGQGAAVK
   121  TGSELSPVDG PVPGQMDSGP VYHGDSRQLS ASGVPVNGAR EPAGPSLLGT GGPWRVDQKP
   181  DWEAAPGPAH TARLEDAHDL VAFSAVAEAV SSYGALSTRL YETFNREMSR EAGNNSRGPR
   241  PGPEGCSAGS EDLDTLQTAL ALARHGMKPP NCNCDGPECP DYLEWLEGKI KSVVMEGGEE
   301  RPRLPGPLPP GEAGLPAPST RPLLSSEVPQ ISPQEGLPLS QSALSIAKEK NISLQTAIAI
   361  EALTQLSSAL PQPSHSTPQA SCPLPEALSP PAPFRSPQSY LRAPSWPVVP PEEHSSFAPD
   421  SSAFPPATPR TEFPEAWGTD TPPATPRSSW PMPRPSPDPM AELEQLLGSA SDYIQSVFKR
   481  PEALPTKPKV KVEAPSSSPA PAPSPVLQRE APTPSSEPDT HQKAQTALQQ HLHHKRSLFL
   541  EQVHDTSFPA PSEPSAPGWW PPPSSPVPRL PDRPPKEKKK KLPTPAGGPV GTEKAAPGIK
   601  PSVRKPIQIK KSRPREAQPL FPPVRQIVLE GLRSPASQEV QAHPPAPLPA SQGSAVPLPP
   661  EPSLALFAPS PSRDSLLPPT QEMRSPSPMT ALQPGSTGPL PPADDKLEEL IRQFEAEFGD
   721  SFGLPGPPSV PIQDPENQQT CLPAPESPFA TRSPKQIKIE SSGAVTVLST TCFHSEEGGQ
   781  EATPTKAENP LTPTLSGFLE SPLKYLDTPT KSLLDTPAKR AQAEFPTCDC VEQIVEKDEG
   841  PYYTHLGSGP TVASIRELME ERYGEKGKAI RIEKVIYTGK EGKSSRGCPI AKWVIRRHTL
   901  EEKLLCLVRH RAGHHCQNAV IVILILAWEG IPRSLGDTLY QELTDTLRKY GNPTSRRCGL
   961  NDDRTCACQG KDPNTCGASF SFGCSWSMYF NGCKYARSKT PRKFRLAGDN PKEEEVLRKS
  1021  FQDLATEVAP LYKRLAPQAY QNQVTNEEIA IDCRLGLKEG RPFAGVTACM DFCAHAHKDQ
  1081  HNLYNGCTVV CTLTKEDNRC VGKIPEDEQL HVLPLYKMAN TDEFGSEENQ NAKVGSGAIQ
  1141  VLTAFPREVR RLPEPAKSCR QRQLEARKAA AEKKKIQKEK LSTPEKIKQE ALELAGITSD
  1201  PGLSLKGGLS QQGLKPSLKV EPQNHFSSFK YSGNAVVESY SVLGNCRPSD PYSMNSVYSY
  1261  HSYYAQPSLT SVNGFHSKYA LPSFSYYGFP SSNPVFPSQF LGPGAWGHSG SSGSFEKKPD
  1321  LHALHNSLSP AYGGAEFAEL PSQAVPTDAH HPTPHHQQPA YPGPKEYLLP KAPLLHSVSR
  1381  DPSPFAQSSN CYNRSIKQEP VDPLTQAEPV PRDAGKMGKT PLSEVSQNGG PSHLWGQYSG
  1441  GPSMSPKRTN GVGGSWGVFS SGESPAIVPD KLSSFGASCL APSHFTDGQW GLFPGEGQQA
  1501  ASHSGGRLRG KPWSPCKFGN STSALAGPSL TEKPWALGAG DFNSALKGSP GFQDKLWNPM
  1561  KGEEGRIPAA GASQLDRAWQ SFGLPLGSSE KLFGALKSEE KLWDPFSLEE GPAEEPPSKG
  1621  AVKEEKGGGG AEEEEEELWS DSEHNFLDEN IGGVAVAPAH GSILIECARR ELHATTPLKK
  1681  PNRCHPTRIS LVFYQHKNLN QPNHGLALWE AKMKQLAERA RARQEEAARL GLGQQEAKLY
  1741  GKKRKWGGTV VAEPQQKEKK GVVPTRQALA VPTDSAVTVS SYAYTKVTGP YSRWI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TET3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

19 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TET3.

Disease | AllUniProt

Conditions TET3 is implicated in, by any mechanism.

• Beck-Fahrner syndrome (BEFAHRS) MIM:618798

Disease | GeneticClinVar

55 pathogenic / likely-pathogenic of 487 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Beck-Fahrner syndrome
• TET3 deficiency
• Inborn genetic diseases
• TET3-related disorder
• Multiple myeloma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.09

gnomAD pLI

1

gnomAD missense Z

2.88

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• epigenetic programing of male pronucleus
• positive regulation of gene expression via chromosomal CpG island demethylation
• positive regulation of transcription by RNA polymerase II
• protein O-linked glycosylation

Molecular functions

• DNA 5-methylcytosine dioxygenase activity
• methyl-CpG binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• chromosome
• cytoplasm
• female pronucleus
• male pronucleus
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, CXXC-type
• 2OGFeDO JBP1/TET, oxygenase domain
• Methylcytosine dioxygenase TET1/2/3
• Methylcytosine dioxygenase TET1-3, oxygenase domain
• CXXC zinc finger domain
• Oxygenase domain of the 2OGFeDO superfamily

KeywordsUniProt

• Chromatin regulator
• Chromosome
• Cytoplasm
• Developmental protein
• Dioxygenase
• DNA-binding
• Intellectual disability
• Iron
• Isopeptide bond
• Metal-binding
• Nucleus
• Oxidoreductase
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of TET3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HCFC1
• OGT
• DCAF1
• METTL23