Seroatlas · Human Serome Atlas

CXXC4

CXXC-type zinc finger protein 4

Also known as: CXXC4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2H0
Gene: CXXC4
Canonical length: 198 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CXXC4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q9H2H0|CXXC4
     1  MHHRNDSQRL GKAGCPPEPS LQMANTNFLS TLSPEHCRPL AGECMNKLKC GAAEAEIMNL
    61  PERVGTFSAI PALGGISLPP GVIVMTALHS PAAASAAVTD SAFQIANLAD CPQNHSSSSS
   121  SSSGGAGGAN PAKKKRKRCG VCVPCKRLIN CGVCSSCRNR KTGHQICKFR KCEELKKKPG
   181  TSLERTPVPS AEAFRWFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXXC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

retina: 6.9 nTPM
hypothalamus: 6.6 nTPM
cerebral cortex: 4.9 nTPM
pituitary gland: 4.2 nTPM
midbrain: 3.5 nTPM
basal ganglia: 3.2 nTPM

Single-cell type

gonadotrophs: 149 nCPM
lactotrophs: 103 nCPM
corticotrophs: 90 nCPM
oligodendrocyte progenitor cells: 83 nCPM
neuroendocrine cells: 74 nCPM
ependymal cells: 71 nCPM

Immune cell

gdT-cell: 0.4 nTPM
memory CD8 T-cell: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 50 nTPM
hypothalamus: 30 nTPM
midbrain: 17 nTPM
medulla oblongata: 14 nTPM
white matter: 14 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.89
gnomAD missense Z: 1.82
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CXXC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DVL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXXC4 as an antibody target. Whether an autoantibody or antibody against CXXC4 could matter depends on whether native CXXC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXXC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CXXC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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