Seroatlas · Human Serome Atlas

CXXC5

CXXC-type zinc finger protein 5

Also known as: CXXC5_HUMAN, HSPC195, RINF, WID

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7LFL8
Gene: CXXC5
Ensembl: ENSG00000171604
Chromosome: 5
Canonical length: 322 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q7LFL8|CXXC5
     1  MSSLGGGSQD AGGSSSSSTN GSGGSGSSGP KAGAADKSAV VAAAAPASVA DDTPPPERRN
    61  KSGIISEPLN KSLRRSRPLS HYSSFGSSGG SGGGSMMGGE SADKATAAAA AASLLANGHD
   121  LAAAMAVDKS NPTSKHKSGA VASLLSKAER ATELAAEGQL TLQQFAQSTE MLKRVVQEHL
   181  PLMSEAGAGL PDMEAVAGAE ALNGQSDFPY LGAFPINPGL FIMTPAGVFL AESALHMAGL
   241  AEYPMQGELA SAISSGKKKR KRCGMCAPCR RRINCEQCSS CRNRKTGHQI CKFRKCEELK
   301  KKPSAALEKV MLPTGAAFRW FQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXXC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 147 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 147 nTPM
spinal cord: 88 nTPM
liver: 85 nTPM
skeletal muscle: 75 nTPM
kidney: 74 nTPM
pancreas: 59 nTPM

Single-cell type

early spermatids: 770 nCPM
late primary spermatocytes: 312 nCPM
esophageal apical cells: 296 nCPM
retinal horizontal cells: 289 nCPM
late spermatids: 251 nCPM
müller glia: 209 nCPM

Immune cell

naive B-cell: 97 nTPM
memory B-cell: 85 nTPM
NK-cell: 72 nTPM
plasmacytoid DC: 59 nTPM
MAIT T-cell: 30 nTPM
total PBMC: 11 nTPM

Brain region

cerebellum: 232 nTPM
white matter: 231 nTPM
medulla oblongata: 213 nTPM
pons: 165 nTPM
spinal cord: 161 nTPM
midbrain: 154 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.89
gnomAD missense Z: 1.58
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CXXC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXXC5 as an antibody target. Whether an autoantibody or antibody against CXXC5 could matter depends on whether native CXXC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXXC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CXXC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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