Seroatlas · Human Serome Atlas

FZD1

Frizzled-1

Also known as: DKFZp564G072, FZD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UP38
Gene
FZD1
Ensembl
ENSG00000157240
Chromosome
7
Canonical length
647 aa
Protein class
Cancer-related genes, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

647 residues, UniProt reviewed canonical sequence.

>Q9UP38|FZD1
     1  MAEEEAPKKS RAAGGGASWE LCAGALSARL AEEGSGDAGG RRRPPVDPRR LARQLLLLLW
    61  LLEAPLLLGV RAQAAGQGPG QGPGPGQQPP PPPQQQQSGQ QYNGERGISV PDHGYCQPIS
   121  IPLCTDIAYN QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ CSAELKFFLC SMYAPVCTVL
   181  EQALPPCRSL CERARQGCEA LMNKFGFQWP DTLKCEKFPV HGAGELCVGQ NTSDKGTPTP
   241  SLLPEFWTSN PQHGGGGHRG GFPGGAGASE RGKFSCPRAL KVPSYLNYHF LGEKDCGAPC
   301  EPTKVYGLMY FGPEELRFSR TWIGIWSVLC CASTLFTVLT YLVDMRRFSY PERPIIFLSG
   361  CYTAVAVAYI AGFLLEDRVV CNDKFAEDGA RTVAQGTKKE GCTILFMMLY FFSMASSIWW
   421  VILSLTWFLA AGMKWGHEAI EANSQYFHLA AWAVPAIKTI TILALGQVDG DVLSGVCFVG
   481  LNNVDALRGF VLAPLFVYLF IGTSFLLAGF VSLFRIRTIM KHDGTKTEKL EKLMVRIGVF
   541  SVLYTVPATI VIACYFYEQA FRDQWERSWV AQSCKSYAIP CPHLQAGGGA PPHPPMSPDF
   601  TVFMIKYLMT LIVGITSGFW IWSGKTLNSW RKFYTRLTNS KQGETTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FZD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 26 nTPM
  • thyroid gland: 20 nTPM
  • seminal vesicle: 16 nTPM
  • heart muscle: 12 nTPM
  • ovary: 12 nTPM
  • vagina: 11 nTPM

Single-cell type

  • retinal horizontal cells: 96 nCPM
  • cholangiocytes: 52 nCPM
  • peritubular myoid cells: 50 nCPM
  • basal prostatic cells: 46 nCPM
  • pituicytes/fscs: 36 nCPM
  • breast secretory cells: 32 nCPM

Immune cell

  • non-classical monocyte: 2.8 nTPM
  • intermediate monocyte: 2 nTPM
  • classical monocyte: 0.6 nTPM
  • myeloid DC: 0.6 nTPM
  • total PBMC: 0.2 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • choroid plexus: 25 nTPM
  • midbrain: 14 nTPM
  • cerebellum: 14 nTPM
  • hippocampal formation: 11 nTPM
  • thalamus: 8.5 nTPM
  • hypothalamus: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.04
gnomAD missense Z
1.8
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FZD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FZD1 as an antibody target. Whether an autoantibody or antibody against FZD1 could matter depends on whether native FZD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FZD1 is annotated at the cell surface, where native FZD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FZD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FZD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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