Seroatlas · Human Serome Atlas

FZD3

Frizzled-3

Also known as: FZD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPG1
Gene
FZD3
Ensembl
ENSG00000104290
Chromosome
8
Canonical length
666 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Vesicles

OverviewNCBI Gene

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>Q9NPG1|FZD3
     1  MAMTWIVFSL WPLTVFMGHI GGHSLFSCEP ITLRMCQDLP YNTTFMPNLL NHYDQQTAAL
    61  AMEPFHPMVN LDCSRDFRPF LCALYAPICM EYGRVTLPCR RLCQRAYSEC SKLMEMFGVP
   121  WPEDMECSRF PDCDEPYPRL VDLNLAGEPT EGAPVAVQRD YGFWCPRELK IDPDLGYSFL
   181  HVRDCSPPCP NMYFRREELS FARYFIGLIS IICLSATLFT FLTFLIDVTR FRYPERPIIF
   241  YAVCYMMVSL IFFIGFLLED RVACNASIPA QYKASTVTQG SHNKACTMLF MILYFFTMAG
   301  SVWWVILTIT WFLAAVPKWG SEAIEKKALL FHASAWGIPG TLTIILLAMN KIEGDNISGV
   361  CFVGLYDVDA LRYFVLAPLC LYVVVGVSLL LAGIISLNRV RIEIPLEKEN QDKLVKFMIR
   421  IGVFSILYLV PLLVVIGCYF YEQAYRGIWE TTWIQERCRE YHIPCPYQVT QMSRPDLILF
   481  LMKYLMALIV GIPSVFWVGS KKTCFEWASF FHGRRKKEIV NESRQVLQEP DFAQSLLRDP
   541  NTPIIRKSRG TSTQGTSTHA SSTQLAMVDD QRSKAGSIHS KVSSYHGSLH RSRDGRYTPC
   601  SYRGMEERLP HGSMSRLTDH SRHSSSHRLN EQSRHSSIRD LSNNPMTHIT HGTSMNRVIE
   661  EDGTSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FZD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • retina: 14 nTPM
  • cerebral cortex: 9 nTPM
  • ovary: 7.8 nTPM
  • choroid plexus: 7.6 nTPM
  • epididymis: 6.6 nTPM
  • blood vessel: 6.4 nTPM

Single-cell type

  • ependymal cells: 381 nCPM
  • choroid plexus epithelial cells: 236 nCPM
  • bergmann glia: 224 nCPM
  • pituitary stem cells: 171 nCPM
  • rod photoreceptor cells: 154 nCPM
  • brain inhibitory neurons: 146 nCPM

Immune cell

  • plasmacytoid DC: 9.3 nTPM
  • memory CD8 T-cell: 2.3 nTPM
  • MAIT T-cell: 2.1 nTPM
  • gdT-cell: 1.6 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • naive CD8 T-cell: 1.6 nTPM

Brain region

  • choroid plexus: 48 nTPM
  • cerebral cortex: 39 nTPM
  • basal ganglia: 32 nTPM
  • midbrain: 31 nTPM
  • cerebellum: 31 nTPM
  • hypothalamus: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FZD3.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 82 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0
gnomAD missense Z
2.64
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FZD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FZD3 as an antibody target. Whether an autoantibody or antibody against FZD3 could matter depends on whether native FZD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FZD3 is annotated at the cell surface, where native FZD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FZD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FZD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...