Seroatlas · Human Serome Atlas

FZD10

Frizzled-10

Also known as: CD350, FZD10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULW2
Gene
FZD10
Ensembl
ENSG00000111432
Chromosome
12
Canonical length
581 aa
Protein class
CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q9ULW2|FZD10
     1  MQRPGPRLWL VLQVMGSCAA ISSMDMERPG DGKCQPIEIP MCKDIGYNMT RMPNLMGHEN
    61  QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS TPIPACRVMC EQARLKCSPI
   121  MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH
   181  PLKDGGPGRG GCDNPGKFHH VEKSASCAPL CTPGVDVYWS REDKRFAVVW LAIWAVLCFF
   241  SSAFTVLTFL IDPARFRYPE RPIIFLSMCY CVYSVGYLIR LFAGAESIAC DRDSGQLYVI
   301  QEGLESTGCT LVFLVLYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAN SSYFHLAAWA
   361  IPAVKTILIL VMRRVAGDEL TGVCYVGSMD VNALTGFVLI PLACYLVIGT SFILSGFVAL
   421  FHIRRVMKTG GENTDKLEKL MVRIGLFSVL YTVPATCVIA CYFYERLNMD YWKILAAQHK
   481  CKMNNQTKTL DCLMAASIPA VEIFMVKIFM LLVVGITSGM WIWTSKTLQS WQQVCSRRLK
   541  KKSRRKPASV ITSGGIYKKA QHPQKTHHGK YEIPAQSPTC V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FZD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 16 nTPM
  • skin: 8.9 nTPM
  • vagina: 6.7 nTPM
  • cervix: 6.1 nTPM
  • salivary gland: 3.7 nTPM
  • prostate: 2.7 nTPM

Single-cell type

  • esophageal apical cells: 66 nCPM
  • esophageal suprabasal cells: 24 nCPM
  • lymphatic endothelial cells: 21 nCPM
  • fibroblasts: 15 nCPM
  • esophageal basal cells: 13 nCPM
  • suprabasal keratinocytes: 11 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 6.1 nTPM
  • cerebellum: 2.9 nTPM
  • pons: 2.7 nTPM
  • white matter: 2.6 nTPM
  • medulla oblongata: 2.5 nTPM
  • midbrain: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FZD10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FZD10 as an antibody target. Whether an autoantibody or antibody against FZD10 could matter depends on whether native FZD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FZD10 is annotated at the cell surface, where native FZD10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FZD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FZD10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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