Seroatlas · Human Serome Atlas

FZD6

Frizzled-6

Also known as: FZD6_HUMAN, Hfz6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60353
Gene
FZD6
Ensembl
ENSG00000164930
Chromosome
8
Canonical length
706 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins
Subcellular location
Plasma membrane,Primary cilium,Basal body

OverviewNCBI Gene

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

706 residues, UniProt reviewed canonical sequence.

>O60353|FZD6
     1  MEMFTFLLTC IFLPLLRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD QSIAAVEMEH
    61  FLPLANLECS PNIETFLCKA FVPTCIEQIH VVPPCRKLCE KVYSDCKKLI DTFGIRWPEE
   121  LECDRLQYCD ETVPVTFDPH TEFLGPQKKT EQVQRDIGFW CPRHLKTSGG QGYKFLGIDQ
   181  CAPPCPNMYF KSDELEFAKS FIGTVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC
   241  YSIVSLMYFI GFLLGDSTAC NKADEKLELG DTVVLGSQNK ACTVLFMLLY FFTMAGTVWW
   301  VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGTPGFLTV MLLAMNKVEG DNISGVCFVG
   361  LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF
   421  SGLYLVPLVT LLGCYVYEQV NRITWEITWV SDHCRQYHIP CPYQAKAKAR PELALFMIKY
   481  LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK
   541  KKHYKPSSHK LKVISKSMGT STGATANHGT SAVAITSHDY LGQETLTEIQ TSPETSMREV
   601  KADGASTPRL REQDCGEPAS PAASISRLSG EQVDGKGQAG SVSESARSEG RISPKSDITD
   661  TGLAQSNNLQ VPSSSEPSSL KGSTSLLVHP VSGVRKEQGG GCHSDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FZD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 24 nTPM
  • skin: 23 nTPM
  • fallopian tube: 22 nTPM
  • thyroid gland: 21 nTPM
  • urinary bladder: 20 nTPM
  • esophagus: 18 nTPM

Single-cell type

  • alveolar cells type 1: 210 nCPM
  • endometrial luminal cells: 162 nCPM
  • distal convoluted tubule cells: 134 nCPM
  • pituitary stem cells: 128 nCPM
  • adrenal cortex cells: 127 nCPM
  • endometrial ciliated cells: 125 nCPM

Immune cell

  • NK-cell: 4 nTPM
  • naive CD4 T-cell: 0.9 nTPM
  • memory CD4 T-cell: 0.8 nTPM
  • memory B-cell: 0.5 nTPM
  • naive B-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • choroid plexus: 7.8 nTPM
  • medulla oblongata: 3.8 nTPM
  • pons: 3.7 nTPM
  • thalamus: 2.6 nTPM
  • white matter: 2.5 nTPM
  • cerebellum: 2.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FZD6.

Disease | AllUniProt

Conditions FZD6 is implicated in, by any mechanism.

  • Nail disorder, non-syndromic congenital, 1 (NDNC1) MIM:161050

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 111 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
1.4
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FZD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FZD6 as an antibody target. Whether an autoantibody or antibody against FZD6 could matter depends on whether native FZD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FZD6 is annotated at the cell surface, where native FZD6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FZD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FZD6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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