Seroatlas · Human Serome Atlas

FBXO47

F-box only protein 47

Also known as: FBX47_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5MNV8
Gene: FBXO47
Ensembl: ENSG00000204952
Chromosome: 17
Canonical length: 452 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FBXO47 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q5MNV8|FBXO47
     1  MASRINTNFT LIPNQKLRRS NRQTSCYSKT LGSGFQPIST FGNFKALPLE IFQIILKYLS
    61  VKDISMLSMV SKTVSQHIIN YISTSSGSKR LLLQDFHNLE LPDRRQDSAI LEHYRSLGLL
   121  FKRCTLLLPT KERLKYIHKI LTEVSCFKFN GCAAPMQCLG LTCYGMFLQT LTAGWDELEC
   181  HRVYNFLCEL TNLCRKIQMA VCSKPGSAQK LELRIRLFCR NVLLDHWTHR SDSAFWLTRI
   241  LKPWPMVNQA RLLYIIFGPI SPQDGQVVWQ EMIEEPTDEF SLKGLADAIK LLYDASTKEW
   301  TADDVISLVD ELSVVPREWL LENNARLLML SGNNICFSFM ASKAVNGRTI ELARLVVFLA
   361  LVCEKELYCM DWTVKMMQKV CKVFSTPVER KNFLQNVANA FACVIMEMLQ SIMSGDRDED
   421  DRSFLNLFHL VHAQANFHKE VLYLTMNTPL ST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

testis: 3.6 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 131 nCPM
undifferentiated spermatogonia: 12 nCPM
hepatic stellate cells: 6.5 nCPM
lacrimal acinar cells: 2.7 nCPM
breast myoepithelial cells: 2.6 nCPM
late primary spermatocytes: 2.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.04
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

F-box domain
F-box-like domain superfamily
F-box domain
F-box only protein 47
FBXO47, ARM repeats region
FBXO47, ARM repeats

KeywordsUniProt

Ubl conjugation pathway

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO47 as an antibody target. Whether an autoantibody or antibody against FBXO47 could matter depends on whether native FBXO47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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