Homeobox domain-containing regulator
IPR051306
Definition
This family of proteins includes transcriptional regulators with homeobox domains that are involved in early embryonic development, axis formation, and myogenesis. Members of this family can act as transcriptional activators or repressors, binding to specific DNA elements to regulate gene expression. Some proteins within this family are implicated in the formation of the Spemann organizer and the Nieuwkoop center, essential for dorsoventral axis formation in embryos. They also play roles in neural induction and the regulation of microRNA expression. Certain family members are associated with muscle regeneration, potentially influencing the expression of myogenic factors and miRNAs. The homeobox domains are key for DNA binding and nuclear localization, while additional regions may contribute to transcriptional activation or repression.
13 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...