DUX1
Double homeobox protein 1
Also known as: DUX1_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for DUX1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
170 residues, UniProt reviewed canonical sequence.
>O43812|DUX1
1 MALLTALDDT LPEEAQGPGR RMILLSTPSQ SDALRACFER NLYPGIATKE ELAQGIDIPE
61 PRVQIWFQNE RSCQLRQHRR QSRPWPGRRD PQKGRRKRTA ITGSQTALLL RAFEKDRFPG
121 IAAREELARE TGLPESRIQI WFQNRRARHR GQSGRAPTQA SIRCNAAPIGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DUX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
OntologyGO
Biological processes
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DUX1 as an antibody target. Whether an autoantibody or antibody against DUX1 could matter depends on whether native DUX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DUX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DUX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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