Seroatlas · Human Serome Atlas

DUX4L4

Double homeobox protein 4-like protein 4

Also known as: DU4L4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CJ87
Gene: DUX4L4
Canonical length: 422 aa

OverviewNCBI Gene

No narrative summary is available for DUX4L4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>P0CJ87|DUX4L4
     1  MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE RLAQAIGIPE
    61  PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA VTGSQTALLL RAFEKDRFPG
   121  IAAREELARE TGLPESRIQI WFQNRRARHP GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF
   181  AHTGAWGTGL PAPHVPCAPG ALPQGAFVSQ AARAAPALQP SQAAPAEGVS QPAPARGDFA
   241  YAAPAPPDGA LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA
   301  PPTSQGSPWW GWGRGPQVAG AAWEPQAGEA PPPQPAPPDA SARQGQMQGI PAPSQALQEP
   361  APWSALPCGL LLDELLASPE FLQQAQPLLE TEAPGELEAS EEAASLEAPL SEEEYRALLE
   421  EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUX4L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -7.41

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUX4L4 as an antibody target. Whether an autoantibody or antibody against DUX4L4 could matter depends on whether native DUX4L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUX4L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUX4L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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