Seroatlas · Human Serome Atlas

DUXB

Double homeobox protein B

Also known as: DUXB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PPF3
Gene
DUXB
Ensembl
ENSG00000282757
Chromosome
16
Canonical length
345 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>A0A1W2PPF3|DUXB
     1  MNLEGTSGGI LQKEFWRNRI QYNQSQKDIL QSWFQHDPFP DKAAREQLAK EIGVPESNIQ
    61  VWFKNYRVKQ RKLDYKCFSE KDQTQGHDQS QHLTQEYLPK EARQKQTFIT WTQKNRLVQA
   121  FERNPFPDIA TRKKLAEQTG LQESRIQMWF QKQRSLYLKK SRMEPMNLLV DDPNERPDAT
   181  VGWHPINLFL PTDSSHYFSC SHSSSGHETL PPVLPSTQAP WDPFRFHVSQ GPNVMIMQPT
   241  QAVQEGEKSD QPLIIPNHLL TLPILTKDLD TPTPFWLQYQ EEHQNHKEHS GSGVPQVKSH
   301  SQPEPEHREQ QPLNLGQFDI SNILQRWDEI CQALLAEWDP LKGTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUXB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • retina: 0.6 nTPM
  • testis: 0.3 nTPM
  • bone marrow: 0.1 nTPM
  • ovary: 0.1 nTPM
  • skin: 0.1 nTPM
  • thyroid gland: 0.1 nTPM

Single-cell type

  • oocytes: 9.2 nCPM
  • epicardial cells: 9.1 nCPM
  • cardiomyocytes: 8.7 nCPM
  • fibro-adipogenic progenitors: 7.6 nCPM
  • cone photoreceptor cells: 6.2 nCPM
  • myonuclei: 5.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 2.7 nTPM
  • basal ganglia: 2.5 nTPM
  • medulla oblongata: 2.5 nTPM
  • cerebral cortex: 2.3 nTPM
  • hippocampal formation: 2.1 nTPM
  • pons: 2.1 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUXB as an antibody target. Whether an autoantibody or antibody against DUXB could matter depends on whether native DUXB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUXB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUXB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DUXB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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