Seroatlas · Human Serome Atlas

DUXA

Double homeobox protein A

Also known as: DUXA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NLW8
Gene: DUXA
Ensembl: ENSG00000258873
Chromosome: 19
Canonical length: 204 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>A6NLW8|DUXA
     1  MAEDTYSHKM VKTNHRRCRT KFTEEQLKIL INTFNQKPYP GYATKQKLAL EINTEESRIQ
    61  IWFQNRRARH GFQKRPEAET LESSQSQGQD QPGVEFQSRE ARRCRTTYSA SQLHTLIKAF
   121  MKNPYPGIDS REELAKEIGV PESRVQIWFQ NRRSRLLLQR KREPVASLEQ EEQGKIPEGL
   181  QGAEDTQNGT NFTSDSHFSG ARTW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUXA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 0.2 nTPM
adipose tissue: 0.1 nTPM
appendix: 0.1 nTPM
choroid plexus: 0.1 nTPM
duodenum: 0.1 nTPM
endometrium: 0.1 nTPM

Single-cell type

late spermatids: 1.6 nCPM
sertoli cells: 1.1 nCPM
neuroendocrine cells: 0.8 nCPM
vascular smooth muscle cells: 0.6 nCPM
undifferentiated spermatogonia: 0.4 nCPM
cardiomyocytes: 0.3 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 1.6 nTPM
hypothalamus: 1.6 nTPM
thalamus: 1.5 nTPM
white matter: 1.5 nTPM
basal ganglia: 1.4 nTPM
cerebellum: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUXA as an antibody target. Whether an autoantibody or antibody against DUXA could matter depends on whether native DUXA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUXA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUXA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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