DUX4L9
Double homeobox protein 4C
Also known as: DUX4C_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for DUX4L9 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
374 residues, UniProt reviewed canonical sequence.
>Q6RFH8|DUX4L9
1 MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE RLAQAIGIPE
61 PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA VTGSQTALLL RAFEKDRFPG
121 IAAREELARE TGLPESRIQI WFQNRRARHP GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF
181 AHTGAWGTGL PAPHVPCAPG ALPQGAFVSQ AARAAPALQP SQAAPAEGIS QPAPARGDFA
241 YAAPAPPDGA LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA
301 PPTSQGSPWW GWGRGPQVAG AAWEPQAGAA PPPQPAPPDA SAASTDASHP GASQPLQEPG
361 RSSTVTSSLL YELLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DUX4L9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
OntologyGO
Biological processes
- cell population proliferation
- positive regulation of transcription by RNA polymerase II
- regulation of gene expression
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- transcription cis-regulatory region binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DUX4L9 as an antibody target. Whether an autoantibody or antibody against DUX4L9 could matter depends on whether native DUX4L9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DUX4L9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DUX4L9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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