DUX3
Putative double homeobox protein 3
Also known as: DUX3_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for DUX3 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
197 residues, UniProt reviewed canonical sequence.
>Q96PT4|DUX3
1 MPAEVHGSPP ASLCPCPSVK FRPGLPAMAL LTALDDTLPE EAQGPGRRMI LLSTPSQSDA
61 LRACFERNLY PGIATKEQLA QGIDIPEPRV QIWFQNERSC QLRQHRRQSR PWPGRRDPQK
121 GRRKRTAITG SQTALLLRAF EKDRFPGIPA REELARETGL PESRIQLWFQ NRRARHWGQS
181 GRAPTQASIR CNAAPIGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DUX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DUX3 as an antibody target. Whether an autoantibody or antibody against DUX3 could matter depends on whether native DUX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DUX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DUX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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