Seroatlas · Human Serome Atlas

ANKRD29

Ankyrin repeat domain-containing protein 29

Also known as: ANR29_HUMAN, FLJ25053

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6D5
Gene: ANKRD29
Ensembl: ENSG00000154065
Chromosome: 18
Canonical length: 301 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q8N6D5|ANKRD29
     1  MCRMSFKKET PLANAAFWAA RRGNLALLKL LLNSGRVDVD CRDSHGTTLL MVAAYAGHID
    61  CVRELVLQGA DINLQRESGT TALFFAAQQG HNDVVRFLFG FGASTEFRTK DGGTALLAAS
   121  QYGHMQVVET LLKHGANIHD QLYDGATALF LAAQGGYLDV IRLLLASGAK VNQPRQDGTA
   181  PLWIASQMGH SEVVRVMLLR GADRDAARND GTTALLKAAN KGYNDVIKEL LKFSPTLGIL
   241  KNGTSALHAA VLSGNIKTVA LLLEAGADPS LRNKANELPA ELTKNERILR LLRSKEGPRK
   301  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

lung: 30 nTPM
parathyroid gland: 23 nTPM
lymph node: 19 nTPM
adipose tissue: 17 nTPM
breast: 15 nTPM
ovary: 15 nTPM

Single-cell type

alveolar cells type 1: 491 nCPM
corticotrophs: 108 nCPM
parietal cells: 90 nCPM
pituicytes/fscs: 87 nCPM
choroid plexus epithelial cells: 79 nCPM
gonadotrophs: 77 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

midbrain: 30 nTPM
amygdala: 27 nTPM
hippocampal formation: 26 nTPM
cerebral cortex: 26 nTPM
medulla oblongata: 22 nTPM
pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD29 as an antibody target. Whether an autoantibody or antibody against ANKRD29 could matter depends on whether native ANKRD29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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