ANKRD65
Ankyrin repeat domain-containing protein 65
Also known as: ANR65_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- E5RJM6
- Gene
- ANKRD65
- Ensembl
- ENSG00000235098
- Chromosome
- 1
- Canonical length
- 399 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Microtubules,Mitotic spindle,Primary cilium,Primary cilium tip
OverviewNCBI Gene
No narrative summary is available for ANKRD65 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
399 residues, UniProt reviewed canonical sequence.
>E5RJM6|ANKRD65
1 MDSQRPEPRE EEEEEQELRW MELDSEEALG TRTEGPSVVQ GWGHLLQAVW RGPAGLVTQL
61 LRQGASVEER DHAGRTPLHL AVLRGHAPLV RLLLQRGAPV GAVDRAGRTA LHEAAWHGHS
121 RVAELLLQRG ASAAARSGTG LTPLHWAAAL GHTLLAARLL EAPGPGPAAA EAEDARGWTA
181 AHWAAAGGRL AVLELLAAGG AGLDGALLVA AAAGRGAALR FLLARGARVD ARDGAGATAL
241 GLAAALGRSQ DIEVLLGHGA DPGIRDRHGR SALHRAAARG HLLAVQLLVT QGAEVDARDT
301 LGLTPLHHAS REGHVEVAGC LLDRGAQVDA TGWLRKTPLH LAAERGHGPT VGLLLSRGAS
361 PTLRTQWAEV AQMPEGDLPQ ALPELGGGEK ECEGIESTGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANKRD65 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 39 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 39 nTPM
- fallopian tube: 35 nTPM
- amygdala: 28 nTPM
- midbrain: 26 nTPM
- hippocampal formation: 25 nTPM
- cerebral cortex: 24 nTPM
Single-cell type
- fallopian tube ciliated cells: 135 nCPM
- breast myoepithelial cells: 84 nCPM
- respiratory ciliated cells: 60 nCPM
- prostatic hillock cells: 45 nCPM
- fallopian secretory cells: 43 nCPM
- smooth muscle cells: 42 nCPM
Immune cell
- plasmacytoid DC: 7.9 nTPM
- myeloid DC: 3.5 nTPM
- naive B-cell: 0.3 nTPM
- naive CD8 T-cell: 0.3 nTPM
- classical monocyte: 0.2 nTPM
- eosinophil: 0.2 nTPM
Brain region
- white matter: 47 nTPM
- medulla oblongata: 40 nTPM
- pons: 36 nTPM
- basal ganglia: 36 nTPM
- midbrain: 34 nTPM
- cerebellum: 28 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.96
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.59
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANKRD65 as an antibody target. Whether an autoantibody or antibody against ANKRD65 could matter depends on whether native ANKRD65 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANKRD65 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ANKRD65 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...