Seroatlas · Human Serome Atlas

ANKRD63

Ankyrin repeat domain-containing protein 63

Also known as: ANR63_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9JTQ0
Gene
ANKRD63
Ensembl
ENSG00000230778
Chromosome
15
Canonical length
380 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

No narrative summary is available for ANKRD63 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>C9JTQ0|ANKRD63
     1  MLKPKDLCPR AGTRTFLEAM QAGKVHLARF VLDALDRSII DCRAEQGRTP LMVAVGLPDP
    61  ALRARFVRLL LEQGAAVNLR DERGRTALSL ACERGHLDAV QLLVQFSGDP EAADSAGNSP
   121  VMWAAACGHG AVLEFLVRSF RRLGLRLDRT NRAGLTALQL AAARGHGTCV QALTGPWGRA
   181  AAAAAARGSN SDSPPGRPAP AASPEHRRPS PRRLPRPLLA RFARAAGGHG GEAGSAGKNS
   241  GRHRAQGSER PELGRSMSLA LGAVTEEEAA RLRAGALMAL PNSPQSSGTG RWRSQEVLEG
   301  APPTLAQAPI GLSPHPEGGP GSGRLGLRRR STAPDIPSLV GEAPGPESGP ELEANALSVS
   361  VPGPNPWQAG TEAVVLRAQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 18 nTPM
  • amygdala: 1.6 nTPM
  • cerebral cortex: 1.4 nTPM
  • hypothalamus: 1.1 nTPM
  • hippocampal formation: 0.8 nTPM
  • heart muscle: 0.7 nTPM

Single-cell type

  • late spermatids: 0.4 nCPM
  • megakaryocyte progenitors: 0.2 nCPM
  • differentiating spermatogonia: 0.1 nCPM
  • undifferentiated spermatogonia: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 35 nTPM
  • cerebral cortex: 9.7 nTPM
  • hypothalamus: 8.7 nTPM
  • amygdala: 4.9 nTPM
  • thalamus: 3.7 nTPM
  • hippocampal formation: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0.38
gnomAD missense Z
1.56

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD63 as an antibody target. Whether an autoantibody or antibody against ANKRD63 could matter depends on whether native ANKRD63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD63 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD63. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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