FAST kinase domain-containing
IPR050870
Definition
The FAST kinase family is involved in various aspects of mitochondrial RNA processing and stability, as well as mitochondrial respiration and translation. Members of this family play crucial roles in the biogenesis of mitochondrial-encoded mRNAs, regulating their abundance and half-lives. They are essential for the assembly and activity of mitochondrial respiratory complexes, such as complex I and IV, by stabilizing specific mRNAs like MT-ND3 and MT-CO1. Some members are also implicated in cell cycle progression and may influence mitochondrial apoptosis. Additionally, the RAP domain within these proteins is vital for RNA-binding and is necessary for their function in mRNA stability and translation. The family also includes proteins that regulate chloroplast RNA homeostasis and are involved in chloroplast development and defense responses.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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