Seroatlas · Human Serome Atlas

TBRG4

FAST kinase domain-containing protein 4

Also known as: Cpr2, FAKD4_HUMAN, FASTKD4, H_TD2522F11.8, KIAA0948

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969Z0
Gene: TBRG4
Ensembl: ENSG00000136270
Chromosome: 7
Canonical length: 631 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables RNA binding activity. Involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>Q969Z0|TBRG4
     1  MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL PGSLMEPVEK
    61  ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA AMVLIRLSHL LSEKPEDKGL
   121  LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL GSLYALGIPK ASKELQSVEQ EVRWRMRKLK
   181  YKHLAFLAES CATLSQEQHS QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN
   241  RLEDKCLELV EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY
   301  AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF EAFAQHVLNR
   361  AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE LPGLEPALQV DLVWALCVLQ
   421  QAREAELQAV LHPEFHIQFL GGKSQKDQNT FQKLLHINAT ALLEYPEYSG PLLPASAVAP
   481  GPSALDRKVT PLQKELQETL KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF
   541  VAPHLAQPTG SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP
   601  FYEWLELKSE WQKGAYLKDK MRKAVAEELA K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBRG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 80 nTPM
tongue: 62 nTPM
heart muscle: 54 nTPM
liver: 42 nTPM
esophagus: 35 nTPM
colon: 35 nTPM

Single-cell type

late primary spermatocytes: 103 nCPM
migrating cytotrophoblasts: 94 nCPM
extravillous trophoblasts: 80 nCPM
cytotrophoblasts: 71 nCPM
esophageal basal cells: 67 nCPM
enteric transient amplifying cells: 58 nCPM

Immune cell

intermediate monocyte: 44 nTPM
non-classical monocyte: 40 nTPM
myeloid DC: 36 nTPM
naive CD4 T-cell: 35 nTPM
naive CD8 T-cell: 33 nTPM
total PBMC: 33 nTPM

Brain region

choroid plexus: 31 nTPM
white matter: 30 nTPM
pons: 30 nTPM
cerebellum: 30 nTPM
medulla oblongata: 29 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial RNA processing
mRNA metabolic process
positive regulation of cell population proliferation
regulation of cell cycle
regulation of mitochondrial mRNA stability
mitochondrial mRNA processing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBRG4 as an antibody target. Whether an autoantibody or antibody against TBRG4 could matter depends on whether native TBRG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBRG4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBRG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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