Seroatlas · Human Serome Atlas

FASTKD5

FAST kinase domain-containing protein 5, mitochondrial

Also known as: FAKD5_HUMAN, FLJ13149

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L8L6
Gene: FASTKD5
Ensembl: ENSG00000215251
Chromosome: 20
Canonical length: 764 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables rRNA binding activity. Involved in mitochondrial RNA processing. Located in mitochondrial nucleoid and ribonucleoprotein granule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

764 residues, UniProt reviewed canonical sequence.

>Q7L8L6|FASTKD5
     1  MAATLKSLKL VRYRAFCSPS AFGAVRSVSY WNVSSTQHGG QDPPEHISLC HSAKKVKNIC
    61  STFSSRRILT TSSAHPGLEF SKTSSSKAST LQLGSPRATG VDEEDVEVFD SFENMRVFLQ
   121  LRPEYRVHSY NASETSQLLS VSEGELILHK VRVNQNNLQA QVIVDYLCKL SSLPAEQHPV
   181  LLGSTSFALL CQLSVKKIQL FDTQDLINVL KAFVILGIPH SHSMLDVYET KCCHQVWEMN
   241  MDQLLLVADL WRYLGRKVPR FLNIFSSYLN LHWKDLSLSQ LVHLIYVIGE NRQVSQDLMQ
   301  KLESLILKYI DLINLEEVGT ICLGFFKSST NLSEFVMRKI GDLACANIQH LSSRSLVNIV
   361  KMFRFTHVDH INFMKQIGEI APQRIPSLGV QGVMHLTLYC SALRFLNEGV MNAVAASLPP
   421  RVAHCRSKDV AKILWSFGTL NYKPPNAEEF YSSLISEIHR KMPEFNQYPE HLPTCLLGLA
   481  FLEYFPVELI DFALSPGFVR LAQERTKFDL LKELYTLDGT VGIECPDYRG NRLSTHLQQE
   541  GSELLWYLAE KDMNSKPEFL ETVFLLETML GGPQYVKHHM ILPHTRSSDL EVQLDVNLKP
   601  LPFNREATPA ENVAKLRLEH VGVSLTDDLM NKLLKGKARG HFQGKTESEP GQQPMELENK
   661  AAVPLGGFLC NVADKSGAME MAGLCPAACM QTPRMKLAVQ FTNRNQYCYG SRDLLGLHNM
   721  KRRQLARLGY RVVELSYWEW LPLLKRTRLE KLAFLHEKVF TSAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FASTKD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 32 nTPM
bone marrow: 31 nTPM
tongue: 25 nTPM
heart muscle: 16 nTPM
kidney: 15 nTPM
adrenal gland: 13 nTPM

Single-cell type

megakaryocytes: 12 nCPM
platelets: 5.6 nCPM
thymic myoid cells: 4.1 nCPM
paneth cells: 3.9 nCPM
endometrial secretory cells: 1 nCPM
innate lymphoid cells: 0.9 nCPM

Immune cell

basophil: 30 nTPM
eosinophil: 20 nTPM
naive CD8 T-cell: 18 nTPM
MAIT T-cell: 18 nTPM
non-classical monocyte: 18 nTPM
T-reg: 18 nTPM

Brain region

choroid plexus: 12 nTPM
cerebellum: 11 nTPM
pons: 8.7 nTPM
cerebral cortex: 8.6 nTPM
medulla oblongata: 7.9 nTPM
white matter: 7.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FASTKD5.

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 111 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Leigh syndrome
Mitochondrial complex IV deficiency, nuclear type 24

Disease | ImmuneIEDB

Conditions an epitope on FASTKD5 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FASTKD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAPK4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FASTKD5 as an antibody target. Whether an autoantibody or antibody against FASTKD5 could matter depends on whether native FASTKD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FASTKD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FASTKD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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