Seroatlas · Human Serome Atlas

FASTKD1

FAST kinase domain-containing protein 1, mitochondrial

Also known as: FAKD1_HUMAN, FLJ21901

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53R41
Gene: FASTKD1
Ensembl: ENSG00000138399
Chromosome: 2
Canonical length: 847 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables RNA binding activity. Involved in mitochondrial RNA metabolic process and regulation of mitochondrial mRNA stability. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

847 residues, UniProt reviewed canonical sequence.

>Q53R41|FASTKD1
     1  MKKTPVFLES LVTNMLRLRA ICPFSWRVFQ FRPISCEPLI IQMNKCTDEE QMFGFIERNK
    61  AILSEKQVGC AFDMLWKLQK QKTSLLKNAE YVRDHPQFLT LHNLATNKFK LMNDDTLVNV
   121  LYVTQQFAGE AHDPLVEALV TEAWRRLERF DIKLLSEFSS CLADQHLYFS PLMGKIADIV
   181  HRNLETTQDL SSLSVLMVNI SSLISRHFQQ QLVNKTELLF DTIDSSEVNV AKSIAKFLRN
   241  VRYRYQPLLE RCNNVFLSNV DHLDLDSISK ILSVYKFLQF NSFEFIIMAK KKLTEMIPLC
   301  NHPASFVKLF VALGPIAGPE EKKQLKSTML LMSEDLTGEQ ALAVLGAMGD MESRNSCLIK
   361  RVTSVLHKHL DGYKPLELLK ITQELTFLHF QRKEFFAKLR ELLLSYLKNS FIPTEVSVLV
   421  RAISLLPSPH LDEVGISRIE AVLPQCDLNN LSSFATSVLR WIQHDHMYLD NMTAKQLKLL
   481  QKLDHYGRQR LQHSNSLDLL RKELKSLKGN TFPESLLEEM IATLQHFMDD INYINVGEIA
   541  SFISSTDYLS TLLLDRIASV AVQQIEKIHP FTIPAIIRPF SVLNYDPPQR DEFLGTCVQH
   601  LNSYLGILDP FILVFLGFSL ATLEYFPEDL LKAIFNIKFL ARLDSQLEIL SPSRSARVQF
   661  HLMELNRSVC LECPEFQIPW FHDRFCQQYN KGIGGMDGTQ QQIFKMLAEV LGGINCVKAS
   721  VLTPYYHKVD FECILDKRKK PLPYGSHNIA LGQLPEMPWE SNIEIVGSRL PPGAERIALE
   781  FLDSKALCRN IPHMKGKSAM KKRHLEILGY RVIQISQFEW NSMALSTKDA RMDYLRECIF
   841  GEVKSCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FASTKD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 26 nTPM
tongue: 25 nTPM
choroid plexus: 22 nTPM
rectum: 21 nTPM
duodenum: 17 nTPM
retina: 17 nTPM

Single-cell type

choroid plexus epithelial cells: 213 nCPM
myonuclei: 172 nCPM
sertoli cells: 111 nCPM
brain inhibitory neurons: 98 nCPM
brain excitatory neurons: 94 nCPM
microglia: 89 nCPM

Immune cell

basophil: 21 nTPM
NK-cell: 7.1 nTPM
myeloid DC: 6.3 nTPM
plasmacytoid DC: 6.2 nTPM
intermediate monocyte: 5.5 nTPM
memory B-cell: 4.9 nTPM

Brain region

choroid plexus: 52 nTPM
cerebellum: 40 nTPM
cerebral cortex: 35 nTPM
white matter: 32 nTPM
pons: 31 nTPM
basal ganglia: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FASTKD1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 145 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Glaucoma 1, open angle, B

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FASTKD1 as an antibody target. Whether an autoantibody or antibody against FASTKD1 could matter depends on whether native FASTKD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FASTKD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FASTKD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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