Histone Modification Regulator
IPR050701
Definition
This family of proteins serves as scaffold subunits within various histone acetyltransferase (HAT) complexes, playing a crucial role in the regulation of gene expression through histone modification. Members of this family are involved in directing the specificity of HAT complexes towards particular lysine residues on histones H3 and H4, facilitating acetylation at these sites. This modification is key to the activation of replication origins and the transcriptional activation of genes throughout development. Some family members also possess histone methyltransferase activity, contributing to the epigenetic transcriptional activation by methylation of histone H3 lysine residues. Additionally, these proteins are implicated in several cellular processes including DNA replication initiation, apoptosis, tumor suppression, and the regulation of signaling pathways. The ubiquitin ligase activity of certain members further extends the family's role in protein post-translational modification and turnover.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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