Seroatlas · Human Serome Atlas

PHF14

PHD finger protein 14

Also known as: KIAA0783, PHF14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94880
Gene: PHF14
Ensembl: ENSG00000106443
Chromosome: 7
Canonical length: 948 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Enables histone binding activity. Predicted to be involved in several processes, including germinal center B cell differentiation; lung development; and negative regulation of mesenchymal cell proliferation involved in lung development. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

948 residues, UniProt reviewed canonical sequence.

>O94880|PHF14
     1  MDRSSKRRQV KPLAASLLEA LDYDSSDDSD FKVGDASDSE GSGNGSEDAS KDSGEGSCSD
    61  SEENILEEEL NEDIKVKEEQ LKNSAEEEVL SSEKQLIKME KKEEEENGER PRKKKEKEKE
   121  KEKEKEKEKE REKEKEKATV SENVAASAAA TTPATSPPAV NTSPSVPTTT TATEEQVSEP
   181  KKWNLRRNRP LLDFVSMEEL NDMDDYDSED DNDWRPTVVK RKGRSASQKE GSDGDNEDDE
   241  DEGSGSDEDE NDEGNDEDHS SPASEGGCKK KKSKVLSRNS ADDEELTNDS LTLSQSKSNE
   301  DSLILEKSQN WSSQKMDHIL ICCVCLGDNS EDADEIIQCD NCGITVHEGC YGVDGESDSI
   361  MSSASENSTE PWFCDACKCG VSPSCELCPN QDGIFKETDA GRWVHIVCAL YVPGVAFGDI
   421  DKLRPVTLTE MNYSKYGAKE CSFCEDPRFA RTGVCISCDA GMCRAYFHVT CAQKEGLLSE
   481  AAAEEDIADP FFAYCKQHAD RLDRKWKRKN YLALQSYCKM SLQEREKQLS PEAQARINAR
   541  LQQYRAKAEL ARSTRPQAWV PREKLPRPLT SSASAIRKLM RKAELMGIST DIFPVDNSDT
   601  SSSVDGRRKH KQPALTADFV NYYFERNMRM IQIQENMAEQ KNIKDKLENE QEKLHVEYNK
   661  LCESLEELQN LNGKLRSEGQ GIWALLGRIT GQKLNIPAIL RAPKERKPSK KEGGTQKTST
   721  LPAVLYSCGI CKKNHDQHLL LLCDTCKLHY HLGCLDPPLT RMPRKTKNSY WQCSECDQAG
   781  SSDMEADMAM ETLPDGTKRS RRQIKEPVKF VPQDVPPEPK KIPIRNTRTR GRKRSFVPEE
   841  EKHEERVPRE RRQRQSVLQK KPKAEDLRTE CATCKGTGDN ENLVRCDECR LCYHFGCLDP
   901  PLKKSPKQTG YGWICQECDS SSSKEDENEA ERKNISQELN MEQKNPKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHF14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 18 nTPM
thymus: 17 nTPM
ovary: 15 nTPM
hippocampal formation: 14 nTPM
amygdala: 13 nTPM
breast: 13 nTPM

Single-cell type

oligodendrocyte progenitor cells: 350 nCPM
thymocytes: 315 nCPM
brain inhibitory neurons: 315 nCPM
brain excitatory neurons: 313 nCPM
corticotrophs: 274 nCPM
megakaryocyte-erythroid progenitors: 272 nCPM

Immune cell

plasmacytoid DC: 2.7 nTPM
naive CD4 T-cell: 1.9 nTPM
T-reg: 1.9 nTPM
memory B-cell: 1.8 nTPM
naive CD8 T-cell: 1.7 nTPM
memory CD8 T-cell: 1.6 nTPM

Brain region

pons: 28 nTPM
cerebellum: 28 nTPM
amygdala: 27 nTPM
hippocampal formation: 27 nTPM
midbrain: 27 nTPM
white matter: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.27
gnomAD missense Z: 2.54
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHF14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HDAC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHF14 as an antibody target. Whether an autoantibody or antibody against PHF14 could matter depends on whether native PHF14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHF14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHF14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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