Seroatlas · Human Serome Atlas

DNAI2

Dynein axonemal intermediate chain 2

Also known as: CILD9, DIC2, DNAI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZS0
Gene
DNAI2
Ensembl
ENSG00000171595
Chromosome
17
Canonical length
605 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Calyx,Connecting piece,Mid piece

OverviewNCBI Gene

The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q9GZS0|DNAI2
     1  MEIVYVYVKK RSEFGKQCNF SDRQAELNID IMPNPELAEQ FVERNPVDTG IQCSISMSEH
    61  EANSERFEME TRGVNHVEGG WPKDVNPLEL EQTIRFRKKV EKDENYVNAI MQLGSIMEHC
   121  IKQNNAIDIY EEYFNDEEAM EVMEEDPSAK TINVFRDPQE IKRAATHLSW HPDGNRKLAV
   181  AYSCLDFQRA PVGMSSDSYI WDLENPNKPE LALKPSSPLV TLEFNPKDSH VLLGGCYNGQ
   241  IACWDTRKGS LVAELSTIES SHRDPVYGTI WLQSKTGTEC FSASTDGQVM WWDIRKMSEP
   301  TEVVILDITK KEQLENALGA ISLEFESTLP TKFMVGTEQG IVISCNRKAK TSAEKIVCTF
   361  PGHHGPIYAL QRNPFYPKNF LTVGDWTARI WSEDSRESSI MWTKYHMAYL TDAAWSPVRP
   421  TVFFTTRMDG TLDIWDFMFE QCDPTLSLKV CDEALFCLRV QDNGCLIACG SQLGTTTLLE
   481  VSPGLSTLQR NEKNVASSMF ERETRREKIL EARHREMRLK EKGKAEGRDE EQTDEELAVD
   541  LEALVSKAEE EFFDIIFAEL KKKEADAIKL TPVPQQPSPE EDQVVEEGEE AAGEEGDEEV
   601  EEDLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 29 nTPM
  • testis: 18 nTPM
  • choroid plexus: 5.4 nTPM
  • lung: 2.9 nTPM
  • hypothalamus: 1.5 nTPM
  • hippocampal formation: 1.4 nTPM

Single-cell type

  • respiratory ciliated cells: 480 nCPM
  • fallopian tube ciliated cells: 253 nCPM
  • ependymal cells: 212 nCPM
  • epididymal efferent duct ciliated cells: 187 nCPM
  • endometrial ciliated cells: 169 nCPM
  • late primary spermatocytes: 124 nCPM

Immune cell

  • NK-cell: 3.8 nTPM
  • memory CD4 T-cell: 0.5 nTPM
  • MAIT T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • T-reg: 0.3 nTPM
  • gdT-cell: 0.2 nTPM

Brain region

  • choroid plexus: 14 nTPM
  • midbrain: 8.8 nTPM
  • medulla oblongata: 6.7 nTPM
  • spinal cord: 4.8 nTPM
  • pons: 3.1 nTPM
  • hypothalamus: 2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAI2.

Disease | AllUniProt

Conditions DNAI2 is implicated in, by any mechanism.

Disease | GeneticClinVar

116 pathogenic / likely-pathogenic of 923 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAI2 as an antibody target. Whether an autoantibody or antibody against DNAI2 could matter depends on whether native DNAI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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