Seroatlas · Human Serome Atlas

WDR90

WD repeat-containing protein 90

Also known as: C16orf15, C16orf16, C16orf17, C16orf18, C16orf19, FLJ36483, KIAA1924, POC16, WDR90_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KV7
Gene: WDR90
Ensembl: ENSG00000161996
Chromosome: 16
Canonical length: 1748 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centrosome,Basal body

OverviewNCBI Gene

Enables microtubule binding activity. Involved in centriole elongation and cilium assembly. Located in microtubule organizing center and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1748 residues, UniProt reviewed canonical sequence.

>Q96KV7|WDR90
     1  MARAWQHPFL NVFRHFRVDE WKRSAKQGDV AVVTDKTLKG AVYRIRGSVS AANYIQLPKS
    61  STQSLGLTGR YLYVLFRPLP SKHFVIHLDV SSKDNQVIRV SFSNLFKEFK STATWLQFPL
   121  VLEARTPQRD LVGLAPSGAR WTCLQLDLQD VLLVYLNRCY GHLKSIRLCA SLLVRNLYTS
   181  DLCFEPAISG AQWAKLPVTP MPREMAFPVP KGESWHDRYI HVRFPSESLK VPSKPIEKSC
   241  SPPEAVLLGP GPQPLPCPVA SSKPVRFSVS PVVQTPSPTA SGRAALAPRP FPEVSLSQER
   301  SDASNADGPG FHSLEPWAQL EASDIHTAAA GTHVLTHESA EVPVARTGSC EGFLPDPVLR
   361  LKGVIGFGGH GTRQALWTPD GAAVVYPCHA VIVVLLVDTG EQRFFLGHTD KVSALALDGS
   421  SSLLASAQAR APSVMRLWDF QTGRCLCLFR SPMHVVCSLS FSDSGALLCG VGKDHHGRTM
   481  VVAWGTGQVG LGGEVVVLAK AHTDFDVQAF RVTFFDETRM ASCGQGSVRL WRLRGGVLRS
   541  CPVDLGEHHA LQFTDLAFKQ ARDGCPEPSA AMLFVCSRSG HILEIDCQRM VVRHARRLLP
   601  TRTPGGPHPQ KQTFSSGPGI AISSLSVSPA MCAVGSEDGF LRLWPLDFSS VLLEAEHEGP
   661  VSSVCVSPDG LRVLSATSSG HLGFLDTLSR VYHMLARSHT APVLALAMEQ RRGQLATVSQ
   721  DRTVRIWDLA TLQQLYDFTS SEDAPCAVTF HPTRPTFFCG FSSGAVRSFS LEAAEVLVEH
   781  TCHRGAVTGL TATPDGRLLF SSCSQGSLAQ YSCADPQWHV LRVAADMVCP DAPASPSALA
   841  VSRDGRLLAF VGPSRCTVTV MGSASLDELL RVDIGTLDLA SSRLDSAMAV CFGPAALGHL
   901  LVSTSSNRVV VLDAVSGRII RELPGVHPEP CPSLTLSEDA RFLLIAAGRT IKVWDYATQA
   961  SPGPQVYIGH SEPVQAVAFS PDQQQVLSAG DAVFLWDVLA PTESDQSFPG APPACKTGPG
  1021  AGPLEDAASR ASELPRQQVP KPCQASPPRL GVCARPPEGG DGARDTRNSG APRTTYLASC
  1081  KAFTPARVSC SPHSAKGTCP PPASGGWLRL KAVVGYSGNG RANMVWRPDT GFFAYTCGRL
  1141  VVVEDLHSGA QQHWSGHSAE ISTLALSHSA QVLASASGRS STTAHCQIRV WDVSGGLCQH
  1201  LIFPHSTTVL ALAFSPDDRL LVTLGDHDGR TLALWGTATY DLVSSTRLPE PVHGVAFNPW
  1261  DAGELTCVGQ GTVTFWLLQQ RGADISLQVR REPVPEAVGA GELTSLCYGA PPLLYCGTSS
  1321  GQVCVWDTRA GRCFLSWEAD DGGIGLLLFS GSRLVSGSST GRLRLWAVGA VSELRCKGSG
  1381  ASSVFMEHEL VLDGAVVSAS FDDSVDMGVV GTTAGTLWFV SWAEGTSTRL ISGHRSKVNE
  1441  VVFSPGESHC ATCSEDGSVR VWALASMELV IQFQVLNQSC LCLAWSPPCC GRPEQQRLAA
  1501  GYGDGSLRIF SVSRTAMELK MHPHPVALTT VAFSTDGQTV LSGDKDGLVA VSHPCTGTTF
  1561  RVLSDHQGAP ISTICVTCKE CEDLGVEGTD LWLAASGDQR VSVWASDWLR NHCELVDWLS
  1621  FPMPATTETQ GHLPPSLAAF CPWDGALLMY VGPGVYKEVI IYNLCQKQVV EKIPLPFFAM
  1681  SLSLSPGTHL LAVGFAECML RLVDCAMGTA QDFAGHDNAV HLCRFTPSAR LLFTAARNEI
  1741  LVWEVPGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR90 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

testis: 59 nTPM
pituitary gland: 26 nTPM
thyroid gland: 22 nTPM
ovary: 22 nTPM
fallopian tube: 21 nTPM
cervix: 17 nTPM

Single-cell type

respiratory ciliated cells: 63 nCPM
endometrial ciliated cells: 42 nCPM
ependymal cells: 41 nCPM
fallopian tube ciliated cells: 38 nCPM
early primary spermatocytes: 37 nCPM
differentiating spermatogonia: 33 nCPM

Immune cell

memory B-cell: 1.2 nTPM
plasmacytoid DC: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
total PBMC: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

choroid plexus: 5.6 nTPM
cerebellum: 4.6 nTPM
white matter: 4.4 nTPM
midbrain: 4.3 nTPM
medulla oblongata: 4.2 nTPM
hypothalamus: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.93
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
CFA20 domain
Quinoprotein alcohol dehydrogenase-like superfamily
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD repeat Echinoderm Microtubule-associated Protein-like
WD domain, G-beta repeat
CFA20 domain
WDR90, 4th beta-propeller domain
WDR90/POC16, second beta-propeller domain
WDR90, 4th beta-propeller
WDR90/POC16, second beta-propeller

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR90 as an antibody target. Whether an autoantibody or antibody against WDR90 could matter depends on whether native WDR90 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR90 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR90 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...