Seroatlas · Human Serome Atlas

EML5

Echinoderm microtubule-associated protein-like 5

Also known as: EMAL5_HUMAN, EMAP-2, FAP16, HuEMAP-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q05BV3
Gene: EML5
Ensembl: ENSG00000165521
Chromosome: 14
Canonical length: 1969 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1969 residues, UniProt reviewed canonical sequence.

>Q05BV3|EML5
     1  MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR EHRQKFYRGH
    61  SDDIISLALH PERVLVATGQ VGKEPYICIW DSYTVQTISV LKDVHTHGIA CLAFDLDGQR
   121  LVSVGLDSKN AVCVWDWKRG KMLSMAPGHT DRIFDISWDL YQPNKLVSCG VKHIKFWSLC
   181  GNALTPKRGV FGKTGDLQTI LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHAAGI
   241  FSMNACEEGF ATGGRDGCIR LWDLTFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
   301  QDSEIFEIVV QERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR IWSLVDHALI
   361  ARCNMEEPIR CAAVNADGIH LALGMKDGSF TVLRVRDMTE VVHIKDRKEA IHELKYSPDG
   421  TYLAVGCNDS SVDIYGVAQR YKKVGECLGS LSFITHLDWS SDSRYLQTND GNGKRLFYRM
   481  PGGKEVTSTE EIKGVHWASW TCVSGLEVNG IWPKYSDIND INSVDGNYIG QVLVTADDYG
   541  IIKLFRYPCL RKGAKFRKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
   601  DAVHIAPQES LADSHSDESD SDLSDVPELD SEIEQETQLT YRRQVYKEDL PQLKEQCKEK
   661  QKSATSKRRE RAPGNSIRLH FVHGYRGYDC RSNLFYTQIG EIVYHVAAVG VIYNRQQNTQ
   721  RFYLGHDDDI LCLTIHPLKD YVATGQVGRD PSIHIWDTET IKPLSILKGH HQYGVSAVDF
   781  SADGKRLASV GIDDSHTVVL WDWKKGEKLS IARGSKDKIF VVKMNPYVPD KLITAGIKHM
   841  KFWRKAGGGL IGRKGYIGTL GKNDTMMCAV YGWTEEMAFS GTSTGDVCIW RDIFLVKTVK
   901  AHDGPVFSMH ALEKGFVTGG KDGIVALWDD SFERCLKTYA IKRAALAPGS KGLLLEDNPS
   961  IRAISLGHGH ILVGTKNGEI LEVDKSGPIT LLVQGHMEGE VWGLATHPYL PICATVSDDK
  1021  TLRIWDLSPS HCMLAVRKLK KGGRCCCFSP DGKALAVGLN DGSFLMANAD TLEDLVSFHH
  1081  RKDMISDIRF SPGSGKYLAV ASHDSFIDIY NVMSSKRVGI CKGATSYITH IDWDIRGKLL
  1141  QVNTGAKEQL FFEAPRGKKQ TIPSVEVEKI AWASWTSVLG LCCEGIWPVI GEVTDVTASC
  1201  LTSDKMVLAT GDDLGFVKLF RYPTKGKFGK FKRYVAHSTH VTNVRWTYDD SMLVTLGGTD
  1261  MSLMVWTNEM EGYREKRPCD SEESDIDSEE DGGYDSDVTR ENEISYTIRA LSTNIRPMLG
  1321  IKPHLQQKEP SIDERPPVSR APPQPEKLQT NNVGKKKRPI EDLVLELIFG YRGRDCRNNV
  1381  HYLNDGDDII YHTASVGILH NVATGSQSFY QEHNDDILCL TVNQHPKFIN IVATGQVGDS
  1441  ADMSATAPSI HIWDAMNKQT LSILRCYHSK GVCSVSFSAT GKLLLSVGLD PEHTITIWRW
  1501  QEGAKIASRA GHNQRIFVAE FRPDSDTQFV SVGVKHVKFW TLAGRALLSK KGLLSTLEDA
  1561  RMQTMLAIAF GANNLTFTGT ISGDVCVWKD HILCRIVARA HNGPVFAMYT TLRDGLIVTG
  1621  GKERPSKEGG AVKLWDQELR RCRAFRLETG QATDCVRSVC RGKGKILVGT RNAEIIEVGE
  1681  KNAACNILVN GHVDGPIWGL ATHPSRDFFL SAAEDGTVRL WDIADKKMLN KVNLGHAART
  1741  VCYSPEGDMV AIGMKNGEFI ILLVSSLKIW GKKRDRRCAI HDIRFSPDSR YLAVGSSENS
  1801  VDFYDLTLGP TLNRISYCKD IPSFVIQMDF SADSSYLQVS SGCYKRHVYE VPSGKHLMDH
  1861  AAIDRITWAT WTSILGDEVL GIWSRHAEKA DVNCACVSHS GISLVTGDDF GMVKLFDFPC
  1921  PEKFAKHKRF LGHSPHVTNI RFTSGDRHVV SAGGDDCSLF VWKCVHTPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EML5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

ovary: 10 nTPM
retina: 8.4 nTPM
prostate: 4 nTPM
adrenal gland: 3.5 nTPM
cerebellum: 2.6 nTPM
parathyroid gland: 2.2 nTPM

Single-cell type

adrenal medulla cells: 872 nCPM
retinal ganglion cells: 576 nCPM
granulosa cells: 541 nCPM
prostatic glandular cells: 383 nCPM
thyrotrophs: 368 nCPM
cone photoreceptor cells: 335 nCPM

Immune cell

MAIT T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 44 nTPM
midbrain: 18 nTPM
hippocampal formation: 14 nTPM
amygdala: 13 nTPM
basal ganglia: 13 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0
gnomAD missense Z: 2.9
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EML5 as an antibody target. Whether an autoantibody or antibody against EML5 could matter depends on whether native EML5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EML5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EML5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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