Seroatlas · Human Serome Atlas

EML6

Echinoderm microtubule-associated protein-like 6

Also known as: EMAL6_HUMAN, FLJ42562

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMW3
Gene: EML6
Ensembl: ENSG00000214595
Chromosome: 2
Canonical length: 1958 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Mitochondria

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1958 residues, UniProt reviewed canonical sequence.

>Q6ZMW3|EML6
     1  MADRTAPRCQ LRLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR EHSQKFFLGH
    61  NDDIISLALH PDKTLVATGQ VGKEPYICIW DSYNVQTVSL LKDVHTHGVA CLAFDSDGQR
   121  LASVGLDAKN TVCIWDWRKG KLLASATGHS DRIFDISWDP YQPNRVVSCG VKHIKFWTLC
   181  GNALTAKRGI FGKTGDLQTI LCLACAKEDI TYSGALNGDI YVWKGLNLVR TIQGAHSAGI
   241  FSMYACEEGF ATGGRDGCIR LWDTDFKPIT KIDLRETEQG YKGLSIRSVC WKADRLLAGT
   301  QDSEIFEVIV RERDKPMLIL QGHCEGELWA LALHPKKPLA VTGSDDRSVR LWSLADHALI
   361  ARCNMEEAVR SVAFSPDGSQ LALGMKDGSF IVLRVRDMTE VVHIKDRKEV IHEMKFSPDG
   421  SYLAVGSNDG PVDVYAVAQR YKKIGECSKS LSFITHIDWS LDSKYLQTND GAGERLFYRM
   481  PSGKPLTSKE EIKGIPWASW TCVKGPEVSG IWPKYTEVTD INSVDANYNS SVLVSGDDFG
   541  LVKLFKFPCL KRGAKFRKYV GHSAHVTNVR WSHDFQWVLS TGGADHSVFQ WRFIPEGVSN
   601  GMLETAPQEG GADSYSEESD SDLSDVPELD SDIEQEAQIN YDRQVYKEDL PQLKQQSKEK
   661  NHAVPFLKRE KAPEDSLKLQ FIHGYRGYDC RNNLFYTQAG EVVYHIAAVA VVYNRQQHSQ
   721  RLYLGHDDDI LSLTIHPVKD YVATGQVGRD AAIHVWDTQT LKCLSLLKGQ HQRGVCALDF
   781  SADGKCLVSV GLDDFHSIVF WDWKKGEKIA TTRGHKDKIF VVKCNPHHVD KLVTVGIKHI
   841  KFWQQAGGGF TSKRGTFGSV GKLETMMCVS YGRMEDLVFS GAATGDIFIW KDILLLKTVK
   901  AHDGPVFAMY ALDKGFVTGG KDGIVELWDD MFERCLKTYA IKRSALSTSS KGLLLEDNPS
   961  IRAITLGHGH ILVGTKNGEI LEIDKSGPMT LLVQGHMEGE VWGLAAHPLL PICATVSDDK
  1021  TLRIWELSAQ HRMLAVRKLK KGGRCCAFSP DGKALAVGLN DGSFLVVNAD TVEDMVSFHH
  1081  RKEMISDIKF SKDTGKYLAV ASHDNFVDIY NVLTSKRVGI CKGASSYITH IDWDSRGKLL
  1141  QVNSGAREQL FFEAPRGKRH IIRPSEIEKI EWDTWTCVLG PTCEGIWPAH SDITDVNAAS
  1201  LTKDCSLLAT GDDFGFVKLF SYPVKGQHAR FKKYVGHSAH VTNVRWLHND SVLLTVGGAD
  1261  TALMIWTREF VGTQESKLVD SEESDTDVEE DGGYDSDVAR EKAIDYTTKI YAVSIREMEG
  1321  TKPHQQLKEV SVEERPPVSR AAPQPEKLQK NNITKKKKLV EELALDHVFG YRGFDCRNNL
  1381  HYLNDGADII FHTAAAGIVQ NLSTGSQSFY LEHTDDILCL TVNQHPKYRN VVATSQIGTT
  1441  PSIHIWDAMT KHTLSMLRCF HSKGVNYINF SATGKLLVSV GVDPEHTITV WRWQEGAKVA
  1501  SRGGHLERIF VVEFRPDSDT QFVSVGVKHM KFWTLAGSAL LYKKGVIGSL GAAKMQTMLS
  1561  VAFGANNLTF TGAINGDVYV WKDHFLIRLV AKAHTGPVFT MYTTLRDGLI VTGGKERPTK
  1621  EGGAVKLWDQ EMKRCRAFQL ETGQLVECVR SVCRGKGKIL VGTKDGEIIE VGEKNAASNI
  1681  LIDGHMEGEI WGLATHPSKD LFISASNDGT ARIWDLADKK LLNKVSLGHA ARCAAYSPDG
  1741  EMVAIGMKNG EFVILLVNSL KVWGKKRDRK SAIQDIRISP DNRFLAVGSS EHTVDFYDLT
  1801  QGTNLNRIGY CKDIPSFVIQ MDFSADGKYI QVSTGAYKRQ VHEVPLGKQV TEAVVIEKIT
  1861  WASWTSVLGD EVIGIWPRNA DKADVNCACV THAGLNIVTG DDFGLVKLFD FPCTEKFAKH
  1921  KRYFGHSAHV TNIRFSYDDK YVVSTGGDDC SVFVWRCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EML6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

retina: 11 nTPM
tonsil: 8.9 nTPM
lymph node: 6 nTPM
appendix: 3.5 nTPM
cerebellum: 3.2 nTPM
pituitary gland: 2.8 nTPM

Single-cell type

ependymal cells: 371 nCPM
brain excitatory neurons: 284 nCPM
brain inhibitory neurons: 259 nCPM
retinal horizontal cells: 246 nCPM
other brain neurons: 219 nCPM
rod photoreceptor cells: 194 nCPM

Immune cell

basophil: 0.7 nTPM
memory B-cell: 0.4 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 12 nTPM
white matter: 10 nTPM
hypothalamus: 9 nTPM
hippocampal formation: 8.5 nTPM
basal ganglia: 7.9 nTPM
midbrain: 7.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EML6.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 358 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

High myopia

Disease | ImmuneIEDB

Conditions an epitope on EML6 was assayed in.

multiple sclerosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

microtubule binding

Cellular components

microtubule

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EML6 as an antibody target. Whether an autoantibody or antibody against EML6 could matter depends on whether native EML6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EML6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EML6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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