NOCT

Protein identityUniProt · HPA

UniProt accession

Q9UK39

Gene

NOCT

Ensembl

ENSG00000151014

Chromosome

4

Canonical length

431 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q9UK39|NOCT
     1  MFHSPRRLCS ALLQRDAPGL RRLPAPGLRR PLSPPAAVPR PASPRLLAAA SAASGAARSC
    61  SRTVCSMGTG TSRLYSALAK TLNSSAASQH PEYLVSPDPE HLEPIDPKEL LEECRAVLHT
   121  RPPRFQRDFV DLRTDCPSTH PPIRVMQWNI LAQALGEGKD NFVQCPVEAL KWEERKCLIL
   181  EEILAYQPDI LCLQEVDHYF DTFQPLLSRL GYQGTFFPKP WSPCLDVEHN NGPDGCALFF
   241  LQNRFKLVNS ANIRLTAMTL KTNQVAIAQT LECKESGRQF CIAVTHLKAR TGWERFRSAQ
   301  GCDLLQNLQN ITQGAKIPLI VCGDFNAEPT EEVYKHFASS SLNLNSAYKL LSADGQSEPP
   361  YTTWKIRTSG ECRHTLDYIW YSKHALNVRS ALDLLTEEQI GPNRLPSFNY PSDHLSLVCD
   421  FSFTEESDGL S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOCT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

34 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0.04

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• circadian regulation of gene expression
• deadenylation-dependent decapping of nuclear-transcribed mRNA
• mRNA stabilization
• NADP+ metabolic process
• negative regulation of gene expression
• negative regulation of osteoblast differentiation
• P-body assembly
• positive regulation of fat cell differentiation
• regulation of circadian rhythm
• regulation of embryonic development
• response to lipopolysaccharide
• transcription by RNA polymerase II

Molecular functions

• 3'-5'-RNA exonuclease activity
• metal ion binding
• mRNA binding
• poly(A)-specific ribonuclease activity
• NADP phosphatase activity
• NADPH phosphatase activity

Cellular components

• cytoplasm
• mitochondrion
• nucleoplasm
• nucleus
• P-body
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Endonuclease/exonuclease/phosphatase
• Endonuclease/exonuclease/phosphatase superfamily
• CCR4/nocturin mRNA turnover and transcription
• Endonuclease/Exonuclease/phosphatase family
• Nocturnin, deadenylase domain

KeywordsUniProt

• Biological rhythms
• Cytoplasm
• Hydrolase
• Magnesium
• Metal-binding
• Mitochondrion
• Nucleus
• Repressor
• RNA-binding
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of NOCT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PPARG