Seroatlas · Human Serome Atlas

PDE12

2',5'-phosphodiesterase 12

Also known as: 2'-PDE, 3635, DKFZp667B1218, PDE12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6L8Q7
Gene
PDE12
Ensembl
ENSG00000174840
Chromosome
3
Canonical length
609 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables poly(A)-specific ribonuclease activity. Involved in several processes, including cellular response to interferon-alpha; innate immune response; and mRNA catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

609 residues, UniProt reviewed canonical sequence.

>Q6L8Q7|PDE12
     1  MWRLPGARAA LRVIRTAVEK LSRAEAGSQT AAGAMERAVV RCVPSEPKLS LSFALADGSH
    61  KNMQRDQSEP LGRVLSRIAT NALKGHAKAA AAKKSRKSRP NASGGAACSG PGPEPAVFCE
   121  PVVKLYYREE AVAEDVLNVD AWQDGAVLQI GDVKYKVERN PPAFTELQLP RYIMAGFPVC
   181  PKLSLEFGDP ASSLFRWYKE AKPGAAEPEV GVPSSLSPSS PSSSWTETDV EERVYTPSNA
   241  DIGLRLKLHC TPGDGQRFGH SRELESVCVV EAGPGTCTFD HRHLYTKKVT EDALIRTVSY
   301  NILADTYAQT EFSRTVLYPY CAPYALELDY RQNLIQKELT GYNADVICLQ EVDRAVFSDS
   361  LVPALEAFGL EGVFRIKQHE GLATFYRKSK FSLLSQHDIS FYEALESDPL HKELLEKLVL
   421  YPSAQEKVLQ RSSVLQVSVL QSTKDSSKRI CVANTHLYWH PKGGYIRLIQ MAVALAHIRH
   481  VSCDLYPGIP VIFCGDFNST PSTGMYHFVI NGSIPEDHED WASNGEEERC NMSLTHFFKL
   541  KSACGEPAYT NYVGGFHGCL DYIFIDLNAL EVEQVIPLPS HEEVTTHQAL PSVSHPSDHI
   601  ALVCDLKWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDE12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 13 nTPM
  • liver: 9.9 nTPM
  • pancreas: 9.2 nTPM
  • parathyroid gland: 8.6 nTPM
  • duodenum: 8.5 nTPM
  • esophagus: 8.5 nTPM

Single-cell type

  • epicardial cells: 46 nCPM
  • suprabasal keratinocytes: 41 nCPM
  • erythrocyte progenitors: 37 nCPM
  • esophageal apical cells: 35 nCPM
  • basal keratinocytes: 35 nCPM
  • monocyte progenitors: 34 nCPM

Immune cell

  • basophil: 20 nTPM
  • NK-cell: 15 nTPM
  • non-classical monocyte: 14 nTPM
  • T-reg: 13 nTPM
  • intermediate monocyte: 13 nTPM
  • naive CD4 T-cell: 12 nTPM

Brain region

  • white matter: 25 nTPM
  • hypothalamus: 24 nTPM
  • cerebellum: 23 nTPM
  • choroid plexus: 23 nTPM
  • basal ganglia: 22 nTPM
  • spinal cord: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.04
gnomAD missense Z
1.4
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDE12 as an antibody target. Whether an autoantibody or antibody against PDE12 could matter depends on whether native PDE12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDE12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDE12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDE12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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