Seroatlas · Human Serome Atlas

ANGEL2

Protein angel homolog 2

Also known as: ANGE2_HUMAN, Ccr4d, FLJ12793, KIAA0759L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VTE6
Gene
ANGEL2
Ensembl
ENSG00000174606
Chromosome
1
Canonical length
544 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Mitochondria

OverviewNCBI Gene

Enables mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Located in Cajal body and cytoplasm. Is active in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q5VTE6|ANGEL2
     1  MEAWRCVRKG YGHCVVGRGR YPMFPHHSRS LGRDWTTPWE NLQRCCWNRH ISSCMRWPGH
    61  YSRAPYPYFS SRHFSLNWRP PCLFESRTQF QYCNWRPDNL SQTSLIHLSS YVMNAEGDEP
   121  SSKRRKHQGV IKRNWEYICS HDKEKTKILG DKNVDPKCED SENKFDFSVM SYNILSQDLL
   181  EDNSHLYRHC RRPVLHWSFR FPNILKEIKH FDADVLCLQE VQEDHYGAEI RPSLESLGYH
   241  CEYKMRTGRK PDGCAICFKH SKFSLLSVNP VEFFRPDISL LDRDNVGLVL LLQPKIPYAA
   301  CPAICVANTH LLYNPRRGDI KLTQLAMLLA EISSVAHQKD GSFCPIVMCG DFNSVPGSPL
   361  YSFIKEGKLN YEGLPIGKVS GQEQSSRGQR ILSIPIWPPN LGISQNCVYE VQQVPKVEKT
   421  DSDLTQTQLK QTEVLVTAEK LSSNLQHHFS LSSVYSHYFP DTGIPEVTTC HSRSAITVDY
   481  IFYSAEKEDV AGHPGAEVAL VGGLKLLARL SLLTEQDLWT VNGLPNENNS SDHLPLLAKF
   541  RLEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANGEL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 15 nTPM
  • cerebellum: 13 nTPM
  • hippocampal formation: 11 nTPM
  • amygdala: 11 nTPM
  • lymph node: 9.8 nTPM
  • breast: 9.7 nTPM

Single-cell type

  • cardiomyocytes: 103 nCPM
  • myonuclei: 77 nCPM
  • adipocytes: 67 nCPM
  • oligodendrocytes: 66 nCPM
  • microglia: 65 nCPM
  • prostatic glandular cells: 60 nCPM

Immune cell

  • NK-cell: 11 nTPM
  • T-reg: 8.9 nTPM
  • naive CD4 T-cell: 6.7 nTPM
  • basophil: 6.6 nTPM
  • MAIT T-cell: 6.5 nTPM
  • memory CD4 T-cell: 6.4 nTPM

Brain region

  • basal ganglia: 23 nTPM
  • hypothalamus: 20 nTPM
  • amygdala: 20 nTPM
  • hippocampal formation: 19 nTPM
  • cerebral cortex: 18 nTPM
  • white matter: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
0.88
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANGEL2 as an antibody target. Whether an autoantibody or antibody against ANGEL2 could matter depends on whether native ANGEL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANGEL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANGEL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANGEL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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