Hairy and Enhancer of Split/HEY-related
IPR050370
Definition
The HES/HEY protein family includes transcriptional repressors that play crucial roles in various developmental processes, including neurogenesis, myogenesis, and the regulation of circadian rhythms. Members of this family are characterized by their ability to bind DNA on N-box motifs and sometimes E-box motifs, typically acting as negative regulators of gene expression. They are involved in the Notch signaling pathway, contributing to cell fate determination and maintenance of precursor cells. The family is also implicated in cardiovascular development and somite segmentation. Key features include a basic helix-loop-helix domain, an Orange domain, and a C-terminal WRPW motif that mediates interaction with Groucho/TLE corepressors.
13 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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