Seroatlas · Human Serome Atlas

HES5

Transcription factor HES-5

Also known as: bHLHb38, HES5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TA89
Gene: HES5
Ensembl: ENSG00000197921
Chromosome: 1
Canonical length: 166 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>Q5TA89|HES5
     1  MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH QPNSKLEKAD
    61  ILEMAVSYLK HSKAFVAAAG PKSLHQDYSE GYSWCLQEAV QFLTLHAASD TQMKLLYHFQ
   121  RPPAAPAAPA KEPKAPGAAP PPALSAKATA AAAAAHQPAC GLWRPW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HES5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 15 nTPM
hypothalamus: 13 nTPM
cerebral cortex: 13 nTPM
amygdala: 12 nTPM
hippocampal formation: 5.2 nTPM
skin: 4.8 nTPM

Single-cell type

astrocytes: 87 nCPM
oligodendrocyte progenitor cells: 79 nCPM
bergmann glia: 68 nCPM
oligodendrocytes: 2.2 nCPM
ependymal cells: 1.9 nCPM
other brain neurons: 1.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 45 nTPM
basal ganglia: 40 nTPM
amygdala: 27 nTPM
cerebral cortex: 20 nTPM
thalamus: 14 nTPM
hippocampal formation: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0.25
gnomAD missense Z: -0.59
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HES5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HELT

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HES5 as an antibody target. Whether an autoantibody or antibody against HES5 could matter depends on whether native HES5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HES5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HES5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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