HES2
Transcription factor HES-2
Also known as: bHLHb40, HES2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y543
- Gene
- HES2
- Ensembl
- ENSG00000069812
- Chromosome
- 1
- Canonical length
- 173 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of neurogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
173 residues, UniProt reviewed canonical sequence.
>Q9Y543|HES2
1 MGLPRRAGDA AELRKSLKPL LEKRRRARIN QSLSQLKGLI LPLLGRENSN CSKLEKADVL
61 EMTVRFLQEL PASSWPTAAP LPCDSYREGY SACVARLARV LPACRVLEPA VSARLLEHLW
121 RRAASATLDG GRAGDSSGPS APAPAPASAP EPASAPVPSP PSPPCGPGLW RPWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HES2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 32 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 32 nTPM
- vagina: 18 nTPM
- cervix: 18 nTPM
- skin: 16 nTPM
- placenta: 6.3 nTPM
- colon: 5.7 nTPM
Single-cell type
- syncytiotrophoblasts: 141 nCPM
- esophageal suprabasal cells: 117 nCPM
- ocular epithelial cells: 91 nCPM
- esophageal basal cells: 90 nCPM
- late spermatids: 88 nCPM
- goblet cells: 52 nCPM
Immune cell
- basophil: 2.7 nTPM
- neutrophil: 1 nTPM
- eosinophil: 0.2 nTPM
- naive B-cell: 0.2 nTPM
- NK-cell: 0.2 nTPM
- plasmacytoid DC: 0.2 nTPM
Brain region
- white matter: 2.5 nTPM
- cerebral cortex: 2.2 nTPM
- cerebellum: 2 nTPM
- pons: 2 nTPM
- hippocampal formation: 1.9 nTPM
- medulla oblongata: 1.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.84
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anterior/posterior pattern specification
- regulation of neurogenesis
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- protein dimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HES2 as an antibody target. Whether an autoantibody or antibody against HES2 could matter depends on whether native HES2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HES2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HES2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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