Seroatlas · Human Serome Atlas

ARRDC5

Arrestin domain-containing protein 5

Also known as: ARRD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NEK1
Gene: ARRDC5
Ensembl: ENSG00000205784
Chromosome: 19
Canonical length: 342 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in protein transport and spermatogenesis. Predicted to be located in membrane. Predicted to be active in endosome and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>A6NEK1|ARRDC5
     1  MGDREECLST PQPPMSVVKS IELVLPEDRI YLAGSSIKGQ VILTLNSTLV DPIVKVELVG
    61  RGYVEWSEEA GASCDYSRNV ICNNKADYVH KTKTFPVEDN WLSAGSHTFD FHFNLPPRLP
   121  STFTSKFGHV FYFVQASCMG REHILAKKRM YLLVQGTSTF HKETPFQNPL FVEAEEKVSY
   181  NCCRQGTVCL QIQMERNTFT PGEKVVFTTE INNQTSKCIK TVVFALYAHI QYEGFTPSAE
   241  RRSRLDSSEL LRQEANTPVT RFNTTKVVST FNLPLLLSVS SSTQDGEIMH TRYELVTTVH
   301  LPWSLTSLKA KVPIIITSAS VDSAICQLSE DGVLPVNPDH QN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARRDC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
spleen: 2 nTPM
lymph node: 1.6 nTPM
bone marrow: 1.5 nTPM
thymus: 1.5 nTPM
small intestine: 0.9 nTPM

Single-cell type

early spermatids: 291 nCPM
late primary spermatocytes: 167 nCPM
late spermatids: 65 nCPM
neutrophil progenitors: 46 nCPM
thymocytes: 31 nCPM
pdcs: 28 nCPM

Immune cell

plasmacytoid DC: 1.4 nTPM
eosinophil: 1.2 nTPM
gdT-cell: 1.1 nTPM
naive CD8 T-cell: 1.1 nTPM
memory B-cell: 1 nTPM
naive CD4 T-cell: 1 nTPM

Brain region

thalamus: 2.9 nTPM
white matter: 2.9 nTPM
cerebral cortex: 2.8 nTPM
medulla oblongata: 2.5 nTPM
midbrain: 2.2 nTPM
choroid plexus: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0.01
gnomAD missense Z: -0.51
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARRDC5 as an antibody target. Whether an autoantibody or antibody against ARRDC5 could matter depends on whether native ARRDC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARRDC5 is annotated at the cell surface, where native ARRDC5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARRDC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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