Seroatlas · Human Serome Atlas

ARRDC2

Arrestin domain-containing protein 2

Also known as: ARRD2_HUMAN, CLONE24945, PP2703

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBH0
Gene: ARRDC2
Ensembl: ENSG00000105643
Chromosome: 19
Canonical length: 407 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in protein transport. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q8TBH0|ARRDC2
     1  MLFDKVKAFS VQLDGATAGV EPVFSGGQAV AGRVLLELSS AARVGALRLR ARGRAHVHWT
    61  ESRSAGSSTA YTQSYSERVE VVSHRATLLA PDTGETTTLP PGRHEFLFSF QLPPTLVTSF
   121  EGKHGSVRYC IKATLHRPWV PARRARKVFT VIEPVDINTP ALLAPQAGAR EKVARSWYCN
   181  RGLVSLSAKI DRKGYTPGEV IPVFAEIDNG STRPVLPRAA VVQTQTFMAR GARKQKRAVV
   241  ASLAGEPVGP GQRALWQGRA LRIPPVGPSI LHCRVLHVDY ALKVCVDIPG TSKLLLELPL
   301  VIGTIPLHPF GSRSSSVGSH ASFLLDWRLG ALPERPEAPP EYSEVVADTE EAALGQSPFP
   361  LPQDPDMSLE GPFFAYIQEF RYRPPPLYSE EDPNPLLGDM RPRCMTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARRDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 146 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 146 nTPM
bone marrow: 76 nTPM
parathyroid gland: 75 nTPM
tongue: 51 nTPM
blood vessel: 48 nTPM
lung: 48 nTPM

Single-cell type

salivary duct cells: 107 nCPM
conjunctival goblet cells: 98 nCPM
cholangiocytes: 67 nCPM
innate lymphoid cells: 61 nCPM
lymphatic endothelial cells: 58 nCPM
salivary ionocytes: 56 nCPM

Immune cell

naive CD4 T-cell: 15 nTPM
naive CD8 T-cell: 8.1 nTPM
NK-cell: 7.4 nTPM
memory CD4 T-cell: 6.6 nTPM
non-classical monocyte: 6.5 nTPM
classical monocyte: 6.2 nTPM

Brain region

white matter: 108 nTPM
medulla oblongata: 80 nTPM
midbrain: 71 nTPM
basal ganglia: 71 nTPM
pons: 64 nTPM
cerebral cortex: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein transport

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of ARRDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

WWP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARRDC2 as an antibody target. Whether an autoantibody or antibody against ARRDC2 could matter depends on whether native ARRDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARRDC2 is annotated at the cell surface, where native ARRDC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARRDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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