GLI C2H2-type zinc-finger
IPR050329
Definition
The GLI C2H2-type zinc-finger protein family is characterized by its involvement in transcriptional regulation, with members acting as transcriptional activators or repressors. These proteins play crucial roles in various biological processes including neurogenesis, organogenesis of the central nervous system (CNS), left-right asymmetry specification, and neural crest development. They are known to bind DNA, often recognizing specific GLI-consensus sequences, and can influence the expression of genes related to cell fate determination and developmental patterning. Some family members are also implicated in cellular responses to environmental stressors such as zinc availability, contributing to homeostasis and adaptation.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...