Seroatlas · Human Serome Atlas

ZNF563

Zinc finger protein 563

Also known as: FLJ34797, ZN563_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TA94
Gene: ZNF563
Ensembl: ENSG00000188868
Chromosome: 19
Canonical length: 476 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q8TA94|ZNF563
     1  MDAVAFEDVA VNFTQEEWAL LGPSQKNLYR YVMQETIRNL DCIRMIWEEQ NTEDQYKNPR
    61  RNLRCHMVER FSESKDSSQC GETFSLIRDS IVNNSICPGE DPCQSAECEE VIMGHLSLNS
   121  HIRVDSGHKP HEYQEYGEKP HTHKQRGKAF SYHHSFQSRG RPHTGKKRYE CKECGKTFSS
   181  RRNLRRHMVV QGGNRPYKCK LCGKAFFWPS LLRMHERTHT GEKPYECKQC SKAFPFYSSY
   241  RRHERMHTGE KPYECKQCSK ALPDSSSYIR HERTHTGEKP YTCKQCGKAF SVSSSLRRHE
   301  TTHSAEKPYE CKQCGKTFHH LGSFQIHMKR HTGDRPHKCK ICGKGFDRPS LVRYHERIHT
   361  GEKPYECKQC GKTLSHSSSF RRHMIMHTGG GPHKCKICGK AFVYPSVCQR HEKSHSGEKP
   421  YECKQCGKAL SHSSSFRRHM VMHTGDGPNK CKVCGKAFVY PSVCQRHEKT HWRETI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF563 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
liver: 9.3 nTPM
thyroid gland: 5.1 nTPM
prostate: 4.6 nTPM
heart muscle: 3.8 nTPM
skin: 3.8 nTPM

Single-cell type

early spermatids: 184 nCPM
late primary spermatocytes: 156 nCPM
sertoli cells: 50 nCPM
müller glia: 43 nCPM
late spermatids: 35 nCPM
epididymal efferent duct absorptive cells: 22 nCPM

Immune cell

naive CD4 T-cell: 8.9 nTPM
naive CD8 T-cell: 5.2 nTPM
memory CD4 T-cell: 4.7 nTPM
naive B-cell: 4.2 nTPM
T-reg: 3.9 nTPM
memory B-cell: 3.2 nTPM

Brain region

cerebellum: 10 nTPM
white matter: 9.1 nTPM
basal ganglia: 8 nTPM
hippocampal formation: 8 nTPM
amygdala: 7.9 nTPM
cerebral cortex: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.76
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF563 as an antibody target. Whether an autoantibody or antibody against ZNF563 could matter depends on whether native ZNF563 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF563 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF563 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...