Seroatlas · Human Serome Atlas

ZNF550

Zinc finger protein 550

Also known as: ZN550_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z398
Gene: ZNF550
Canonical length: 422 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ZNF550 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q7Z398|ZNF550
     1  MAETKDAAQM LVTFKDVAVT FTREEWRQLD LAQRTLYREV MLETCGLLVS LGHRVPKPEL
    61  VHLLEHGQEL WIVKRGLSHA TCAGDRAQVH TREPTTYPPV LSERAFLRGS LTLESSTSSD
   121  SRLGRARDEE GLLEMQKGKV TPETDLHKET HLGKVSLEGE GLGTDDGLHS RALQEWLSAD
   181  VLHECDSQQP GKDALIHAGT NPYKCKQCGK GFNRKWYLVR HQRVHTGMKP YECNACGKAF
   241  SQSSTLIRHY LIHTGEKPYK CLECGKAFKR RSYLMQHHPI HTGEKPYECS QCRKAFTHRS
   301  TFIRHNRTHT GEKPFECKEC EKAFSNRAHL IQHYIIHTGE KPYDCMACGK AFRCSSELIQ
   361  HQRIHTGEKP YECTQCGKAF HRSTYLIQHS VIHTGEMPYK CIECGKAFKR RSHLLQHQRV
   421  HT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF550 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

ovary: 3.6 nTPM
skin: 3.5 nTPM
cerebellum: 3.3 nTPM
heart muscle: 3.1 nTPM
pituitary gland: 3.1 nTPM
salivary gland: 3.1 nTPM

Single-cell type

cardiomyocytes: 104 nCPM
myonuclei: 22 nCPM
adipocytes: 18 nCPM
thymocytes: 18 nCPM
choroid plexus epithelial cells: 17 nCPM
retinal pigment epithelial cells: 13 nCPM

Immune cell

naive CD4 T-cell: 3.7 nTPM
gdT-cell: 2.6 nTPM
MAIT T-cell: 2.4 nTPM
memory CD4 T-cell: 2.3 nTPM
T-reg: 2.3 nTPM
NK-cell: 2.2 nTPM

Brain region

cerebellum: 15 nTPM
choroid plexus: 14 nTPM
hypothalamus: 12 nTPM
white matter: 11 nTPM
pons: 11 nTPM
cerebral cortex: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.03
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF550 as an antibody target. Whether an autoantibody or antibody against ZNF550 could matter depends on whether native ZNF550 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF550 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF550 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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