Seroatlas · Human Serome Atlas

ZNF616

Zinc finger protein 616

Also known as: MGC45556, ZN616_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08AN1
Gene: ZNF616
Ensembl: ENSG00000204611
Chromosome: 19
Canonical length: 781 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

781 residues, UniProt reviewed canonical sequence.

>Q08AN1|ZNF616
     1  MATQGHLTFK DVAIEFSQEE WKCLEPVQKA LYKDVMLENY RNLVFLGISP KCVIKELPPT
    61  ENSNTGERFQ TVALERHQSY DIENLYFREI QKHLHDLEFQ WKDGETNDKE VPVPHENNLT
   121  GKRDQHSQGD VENNHIENQL TSNFESRLAE LQKVQTEGRL YECNETEKTG NNGCLVSPHI
   181  REKTYVCNEC GKAFKASSSL INHQRIHTTE KPYKCNECGK AFHRASLLTV HKVVHTRGKS
   241  YQCDVCGKIF RKNSYFVRHQ RSHTGQKPYI CNECGKSFSK SSHLAVHQRI HTGEKPYKCN
   301  LCGKSFSQRV HLRLHQTVHT GERPFKCNEC GKTFKRSSNL TVHQVIHAGK KPYKCDVCGK
   361  AFRHRSNLVC HRRIHSGEKQ YKCNECGKVF SKRSSLAVHR RIHTVEKPCK CNECGKVFSK
   421  RSSLAVHQRI HTGQKTYKCN KCGKVYSKHS HLAVHWRIHT GEKAYKCNEC GKVFSIHSRL
   481  AAHQRIHTGE KPYKCNECGK VFSQHSRLAV HRRIHTGEKP YKCKECGKVF SDRSAFARHR
   541  RIHTGEKPYK CKECGKVFSQ CSRLTVHRRI HSGEKPYKCN ECGKVYSQYS HLVGHRRVHT
   601  GEKPYKCHEC GKAFNQGSTL NRHQRIHTGE KPYKCNQCGN SFSQRVHLRL HQTVHTGDRP
   661  YKCNECGKTF KRSSNLTAHQ IIHAGKKPYK CDECGKVFRH SSHLVSHQRI HTGEKRYKCI
   721  ECGKAFGRLF SLSKHQRIHS GKKPYKCNEC GKSFICRSGL TKHRIRHTGE SLTTKLNVTR
   781  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF616 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 11 nTPM
retina: 8.8 nTPM
ovary: 8.7 nTPM
thyroid gland: 7.3 nTPM
parathyroid gland: 7.2 nTPM
thymus: 6.8 nTPM

Single-cell type

adrenal cortex cells: 12 nCPM
distal convoluted tubule cells: 11 nCPM
renal connecting tubule cells: 9.2 nCPM
renal collecting duct principal cells: 8.4 nCPM
proximal tubule cells: 8.1 nCPM
rod photoreceptor cells: 7.9 nCPM

Immune cell

NK-cell: 13 nTPM
non-classical monocyte: 11 nTPM
gdT-cell: 4.9 nTPM
memory CD4 T-cell: 4.5 nTPM
MAIT T-cell: 4.4 nTPM
memory CD8 T-cell: 3.9 nTPM

Brain region

cerebellum: 24 nTPM
cerebral cortex: 16 nTPM
hypothalamus: 16 nTPM
white matter: 16 nTPM
basal ganglia: 15 nTPM
amygdala: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0.01
gnomAD missense Z: -0.64
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF616 as an antibody target. Whether an autoantibody or antibody against ZNF616 could matter depends on whether native ZNF616 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF616 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF616 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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