Seroatlas · Human Serome Atlas

ZNF728

Zinc finger protein 728

Also known as: ZN728_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DKX0
Gene: ZNF728
Ensembl: ENSG00000269067
Chromosome: 19
Canonical length: 622 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>P0DKX0|ZNF728
     1  MGSLTFRDVA IQFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAPKP DLIIFLEQGK
    61  EPWNMKRHEL VKEPPVICSH FAQDLWPEQG REDSFQKVIL RRYEKCGHEN LQLKIGCTNV
   121  DECKVHKKGY NKLNQSLTTT QSKVFQCGKY ANIFHKCSNS KRHKIRHTGK KLLKCKEYVR
   181  SFCMLSHLSQ HKRIYTRENS YKSEEHGKAF NWSSALTYKR IHTGEKPCKC EECGKAFSKF
   241  SILTKHKVIH TGEKHYKCEE CGKAFTRSSS LIEHKRSHAG EKPYKCEECG KAFSKASTLT
   301  AHKTIHAGEK PYKCEECGKA FNRSSNLMEH KRIHTGEKPC KCEECGKAFG NFSTLTKHKV
   361  IHTGEKPYKC EECGKAFSWP SSLTEHKRIH AGDKPYKCEE CGKTFKWSST LTKHKIIHTG
   421  EKPYKCEECG KAFTTFSSLT KHKVIHTGEK HYKCEECGKV FSWSSSLTTH KAIHAGEKLY
   481  KCEECGKAFK WSSNLMEHKR IHTGEKPYKC EECGKAFSKV ANLTKHKVIH TGEKQYKCEE
   541  CGKAFIWSSR LSEHKRIHTG EKPYKCEECG KAFSWVSVLN KHKKIHAGKK FYKCEECGKD
   601  FNQSSHLTTH KRIHTGGKTL QM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF728 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

testis: 9.7 nTPM
thyroid gland: 1.9 nTPM
parathyroid gland: 1.6 nTPM
ovary: 1.5 nTPM
fallopian tube: 1.3 nTPM
heart muscle: 1.3 nTPM

Single-cell type

cardiomyocytes: 41 nCPM
late primary spermatocytes: 20 nCPM
pituicytes/fscs: 16 nCPM
early primary spermatocytes: 14 nCPM
late spermatids: 12 nCPM
renal collecting duct principal cells: 12 nCPM

Immune cell

NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

midbrain: 10 nTPM
hypothalamus: 9.6 nTPM
basal ganglia: 9.3 nTPM
thalamus: 8.6 nTPM
white matter: 8.6 nTPM
pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: 0.05
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF728 as an antibody target. Whether an autoantibody or antibody against ZNF728 could matter depends on whether native ZNF728 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF728 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF728 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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