Antennapedia-type homeobox
IPR050296
Definition
The Antp homeobox family comprises sequence-specific transcription factors that play a crucial role in the developmental regulatory system. These proteins are responsible for providing cells with specific positional identities along the anterior-posterior axis during development. They are involved in the regulation of segmental identity and pattern formation, controlling cell differentiation in various tissues including epidermal, neuronal, and mesodermal cells. Some family members also have the ability to bind to their own promoters and regulate their expression. The DNA-binding specificity of these transcription factors is often characterized by a conserved motif that they recognize on the DNA. The family is essential for proper development and body segmentation, influencing the fate of cells and tissues in a wide range of organisms from invertebrates to vertebrates.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...