Seroatlas · Human Serome Atlas

HOXC6

Homeobox protein Hox-C6

Also known as: HOX3, HOX3C, HXC6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09630
Gene: HOXC6
Ensembl: ENSG00000197757
Chromosome: 12
Canonical length: 235 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>P09630|HOXC6
     1  MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN
    61  VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI
   121  QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL
   181  TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 31 nTPM
ovary: 26 nTPM
kidney: 21 nTPM
adipose tissue: 19 nTPM
epididymis: 18 nTPM
blood vessel: 18 nTPM

Single-cell type

smooth muscle cells: 3.2 nCPM
pericytes: 0.9 nCPM
epididymal efferent duct ciliated cells: 0.8 nCPM
ovarian stromal cells: 0.8 nCPM
fibroblasts: 0.5 nCPM
vascular smooth muscle cells: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 9.4 nTPM
medulla oblongata: 6.9 nTPM
spinal cord: 6.7 nTPM
white matter: 3.3 nTPM
midbrain: 0.5 nTPM
cerebral cortex: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.51
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOXC6 as an antibody target. Whether an autoantibody or antibody against HOXC6 could matter depends on whether native HOXC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOXC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOXC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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