HOXB7

Protein identityUniProt · HPA

UniProt accession

P09629

Gene

HOXB7

Ensembl

ENSG00000260027

Chromosome

17

Canonical length

217 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>P09629|HOXB7
     1  MSSLYYANTL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS FAASMQGLYP
    61  GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDSAKAAGA KEQRDSDLAA
   121  ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ
   181  IKIWFQNRRM KWKKENKTAG PGTTGQDRAE AEEEEEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOXB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

128 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.52

gnomAD pLI

0

gnomAD missense Z

0.24

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterior/posterior pattern specification
• embryonic organ development
• embryonic skeletal system morphogenesis
• myeloid cell differentiation
• positive regulation of branching involved in ureteric bud morphogenesis
• positive regulation of transcription by RNA polymerase II
• regulation of DNA-templated transcription
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytosol
• nuclear body
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homeobox protein, antennapedia type, conserved site
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeobox protein, antennapedia type
• Homeodomain, metazoa
• Antennapedia-type homeobox
• Homeodomain

KeywordsUniProt

• Developmental protein
• DNA-binding
• Homeobox
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of HOXB7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRKDC
• XRCC5