HOXA5
Homeobox protein Hox-A5
Also known as: HOX1, HOX1C, HXA5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P20719
- Gene
- HOXA5
- Ensembl
- ENSG00000106004
- Chromosome
- 7
- Canonical length
- 270 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
270 residues, UniProt reviewed canonical sequence.
>P20719|HOXA5
1 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG
61 SGHFGSGERA RSYAASASAA PAEPRYSQPA TSTHSPQPDP LPCSAVAPSP GSDSHHGGKN
121 SLSNSSGASA DAGSTHISSR EGVGTASGAE EDAPASSEQA SAQSEPSPAP PAQPQIYPWM
181 RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK
241 IWFQNRRMKW KKDNKLKSMS MAAAGGAFRPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HOXA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 78 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 78 nTPM
- fallopian tube: 55 nTPM
- epididymis: 46 nTPM
- kidney: 24 nTPM
- lung: 19 nTPM
- spinal cord: 18 nTPM
Single-cell type
- breast myoepithelial cells: 4.3 nCPM
- basal prostatic cells: 3.9 nCPM
- adrenal cortex cells: 2.5 nCPM
- epididymal efferent duct absorptive cells: 2.5 nCPM
- innate lymphoid cells: 2.2 nCPM
- hematopoietic stem cells: 1.9 nCPM
Immune cell
- basophil: 0.8 nTPM
- NK-cell: 0.6 nTPM
- neutrophil: 0.4 nTPM
- myeloid DC: 0.1 nTPM
- non-classical monocyte: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
Brain region
- medulla oblongata: 85 nTPM
- spinal cord: 53 nTPM
- white matter: 35 nTPM
- pons: 23 nTPM
- cerebral cortex: 1 nTPM
- midbrain: 1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.23
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.86
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anterior/posterior pattern specification
- bronchiole development
- cell migration
- cell-cell signaling involved in mammary gland development
- embryonic skeletal system morphogenesis
- epithelial tube branching involved in lung morphogenesis
- intestinal epithelial cell maturation
- lung alveolus development
- lung goblet cell differentiation
- lung-associated mesenchyme development
- mammary gland alveolus development
- mammary gland epithelial cell differentiation
- mesenchymal-epithelial cell signaling
- multicellular organism growth
- negative regulation of angiogenesis
- negative regulation of erythrocyte differentiation
- positive regulation of apoptotic process
- positive regulation of gene expression
- positive regulation of myeloid cell differentiation
- positive regulation of transcription by RNA polymerase II
- regulation of mammary gland epithelial cell proliferation
- regulation of transcription by RNA polymerase II
- respiratory system process
- thyroid gland development
- trachea cartilage morphogenesis
Molecular functions
- DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HOXA5 as an antibody target. Whether an autoantibody or antibody against HOXA5 could matter depends on whether native HOXA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HOXA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HOXA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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